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A major advance in colon cancer

23 May 2013 - 10h22 | By INSERM PRESS OFFICE | Cancer

A French consortium of clinicians and biologists has proposed a molecular classification of colon cancers into six sub-types. 

A national multicentric consortium of clinicians, biologists and researchers performed a genomic study as part of the CIT programme (Cartes d’Identité des Tumeurs® [Tumour Identity Cards]) of the Ligue contre le Cancer. The study included tumours from 566 patients suffering from colon cancer, the results of which were published in the international journal PLOS MEDECINE.

In analysing a transcriptome of this cohort that is perfectly described clinically and pathologically, the consortium produced a robust classification into six molecular sub-types that were well-defined in terms of changes to the genome and signalling routes associated with a gene expression signature.

These six sub-types are correlated to separate prognoses. The classification was validated using an independent series of 1,181 colon cancers.

It is planned to apply the signature of each sub-type to other series of colon tumours  with the aim of obtaining a routinely transferable diagnostic tool so as to improve the prognosis and to guide treatment.

Épithélium du côlon

crédit : ©Inserm

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Researcher Contact

Pr. Pierre Laurent-Puig UMRS775 Bases Moléculaires de la réponse aux xénobiotiques 01 42 86 20 81 Dr. Aurélien de Reyniès Programme Cartes d’Identité des Tumeurs, Ligue contre le cancer 01 53 55 25 12


“Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic Value”

L Marisa, A de Reyniès, A Duval, J Selves, MP Gaub, L Vescovo, MC Etienne-Grimaldi, R Schiappa, D Guenot, M Ayadi, S Kirzin, M Chazal, JF Fléjou, D Benchimol, A Berger, A Lagarde, E Pencreach, F Piard, D Elias, Y Parc, S Olschwang, G Milano, P Laurent-Puig,, V Boige

PLOS MEDICINE, 22 mai 2013

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