Regulatory T cells (Treg) are a sub-population of immune cells that prevent each individual from triggering immune reactions against his/her own organs. In the context of some illnesses, these mechanisms may be defective: in this case, the term “auto-immune reactions” is applied. In this new research, published in the Science review, the team of researchers directed by Sebastian Amigorena (Institut Curie / Inserm U932 Immunity and Cancer unit) demonstrates that the regulatory T cells are also important during immune responses to external antigens, i.e. during infection.
By regulating the interactions between cells with antigens and T cells, Treg prefer engaging “high affinity” cells in terms of antigens, thus boosting the immune response. However, if there are no Treg, this first stage of immune response is defective, leading – in time – to an incorrect memorization process of pathogens and, consequently, to reduced defense mechanisms against infection (for example).
crédit photo M Depardieu/Inserm
Scientists from the Institut Pasteur, the Collège de France, Inserm/Imagine-Necker and the Université Paris Descartes have successfully cultured and reproduced the complex life-cycle of these bacteria outside their host for the first time. ...
(Français) L'équipe de recherche montre dans un article publié dans le Journal of the American Society of Nephrology que certains globules blancs activés lors de la réponse immunitaire, les monocytes, exercent un effet protecteur sur le tissu rénal chez des souris modèles ...
« Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory » L. Pace et coll.
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