A French consortium of clinicians and biologists has proposed a molecular classification of colon cancers into six sub-types.
A national multicentric consortium of clinicians, biologists and researchers performed a genomic study as part of the CIT programme (Cartes d’Identité des Tumeurs® [Tumour Identity Cards]) of the Ligue contre le Cancer. The study included tumours from 566 patients suffering from colon cancer, the results of which were published in the international journal PLOS MEDECINE.
In analysing a transcriptome of this cohort that is perfectly described clinically and pathologically, the consortium produced a robust classification into six molecular sub-types that were well-defined in terms of changes to the genome and signalling routes associated with a gene expression signature.
These six sub-types are correlated to separate prognoses. The classification was validated using an independent series of 1,181 colon cancers.
It is planned to apply the signature of each sub-type to other series of colon tumours with the aim of obtaining a routinely transferable diagnostic tool so as to improve the prognosis and to guide treatment.
crédit : ©Inserm
Une équipe internationale de chercheurs dirigée par Toby Lawrence, chercheur Inserm, vient de mettre au point une thérapie potentielle pour réduire la taille des tumeurs, là où les médicaments précédents ont échoué. Ces résultats sont publiés dans le Journal of Experimental Medicine. ...
“Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic Value” L Marisa, A de Reyniès, A Duval, J Selves, MP Gaub, L Vescovo, MC Etienne-Grimaldi, R Schiappa, D Guenot, M Ayadi, S Kirzin, M Chazal, JF Fléjou, D Benchimol, A Berger, A Lagarde, E Pencreach, F Piard, D Elias, Y Parc, S Olschwang, G Milano, P Laurent-Puig,, V Boige PLOS MEDICINE, 22 mai 2013