High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease C. Pottier1,2, D. Hannequin1,2, S. Coutant1,2, A. Rovelet-Lecrux1,2, D. Wallon1,2, S. Rousseau1,2, S. Legallic1,2, C. Paquet3, S. Bombois2,4, J. Pariente5, C. Thomas-Anterion6, A. Michon2,7, B. Croisile8, F. Etcharry-Bouyx9, C. Berr10, J-F. Dartigues11, P. Amouyel12, H. Dauchel13, C. Boutoleau-Bretonnière14, C. Thauvin15, T. Frebourg1, J-C. Lambert12 et D. Campion1,2,16, PHRC GMAJ collaborators17 1Department of Molecular Genetics, Inserm U1079, Institute for Biomedical Research and Innovation, University of Rouen, Rouen, France; 2CNR-MAJ, Rouen University Hospital, Lille University Hospital and Paris Salpêtrière University Hospital, France; 3CMRR Nord, Inserm U839, Lariboisière University Hospital, Paris, France; 4EA1046, Lille Nord University Hospital, Lille, France; 5Department of Neurology, CMRR and Inserm U825, Purpan University Hospital, Toulouse, France; 6Department of Neurology, CMRR, University Hospital Nord, Saint Etienne, France; 7CRCICM, IM2A, UMR-S975 AP-HP, University Hospital Pitié-Salpêtrière, Paris, France; 8Department of Neuropsychology, CMRR, University Hospital, Groupe Hospitalier Est, Bron, France; 9Department of Neurology, Angers University Hospital, Angers, France; 10INSERM U888, Hôpital La Colombière, Montpellier, France; 11INSERM U897, Victor Segalen University, Bordeaux, France; 12INSERM U744, Pasteur Institute of Lille, Lille, France; 13LITIS, EA 4108, University of Rouen, Rouen, France; 14Department of Neurology, CMRR, Nantes University Hospital, Nantes, France; 15Department of Genetics, Dijon University Hospital, Dijon, France and Q2 16Le Rouvray Hospital, Sotteville les Rouen, France Molecular Psychiatry, le 03 avril, doi: 10.1038/mp.2012.15