- 2018
- Press releases - 05.09.2018
Syndecan-1: A Candidate to Activate Neural Stem Cells and Regenerate the Brain
The adult brain has a very limited capacity for regeneration. However, researchers have updated the role of a key membrane molecule in the proliferation of stem cells in the adult mouse brain: Syndecan-1. CEA, Inserm and the Paris-Sud and Paris Diderot universities have joined forces to demonstrate that Syndecan-1, present in the membrane of the neural stem cells, permits their proliferation. Syndecan-1 therefore becomes a possible tracer of brain regeneration, opening up new perspectives in the field of regenerative medicine. This research, for which a patent is pending, was published on August 14 in Stem Cell Reports.
- Press releases - 05.09.2018
Genetic control of human thymic function: Needle in a haystack
A study conducted by a group of researchers from Paris Diderot University, INSERM and the Institut Pasteur reveals the existence of a genetic factor influencing the function of the human thymus. The results of the study, part of the Laboratories of Excellence project Milieu Intérieur coordinated by the Institut Pasteur, are published in the journal Science Translational Medicine on September 5, 2018.
- Press releases - 04.09.2018
Adolescent depression: early signs and changes in brain development underscore the need for new preventive approaches
Teams of AP-HP, Inserm and Université Paris Sud, studied as part of an international research group, depressions called “subsyndromal” among young teenagers as they have a high risk to progress to depression in adolescence and later in adulthood.
- Press releases - 04.09.2018
To Vaccinate is to Protect
Epidemics have no concept of borders! That is why, via Inserm, France is making a commitment to the health of European citizens by creating a European platform to intensify national responses to the challenges posed by vaccination. This European Joint Action on Vaccination (EU-JAV), coordinated by Inserm and backed by the French health ministry, was launched on September 4 with the participation of 19 other European countries.
- Press releases - 31.08.2018
A brain mechanism involved in mediated learning is identified
Imagine that you are eating a Granny apple under a red parasol on the terrace of a public garden. The next day you eat another Granny apple at home in your kitchen, but soon afterwards find yourself ill. The next time you go back to the public garden, you avoid sitting under that red parasol. While there may not seem to be a link between the parasol and the fact that you were ill, there actually is! This is an example of the mediated learning process, and researchers from INRA and INSERM have just identified the brain mechanism involved in it. Their results, published online on 30 August 2018 in Neuron, show that cannabinoid receptors in the hippocampus play a key role in establishing these types of associations.
- Press releases - 31.08.2018
Novel brain network linked to chronic pain in Parkinson’s disease
Des chercheurs de l’Inserm et de l’Université Grenoble Alpes ont révélé un nouveau réseau cérébral qui relie la douleur ressentie dans la maladie de Parkinson à une région spécifique du cerveau. Ces travaux, paru dans la revue eLife, révèlent qu’un sous-ensemble de neurones situé dans une partie du cerveau appelée noyau sous-thalamique serait une cible potentielle pour soulager la douleur dans la maladie de Parkinson, ainsi que dans d’autres maladies comme la démence, la sclérose latérale amyotrophique, la maladie de Huntington, et certaines formes de migraine.
- Press releases - 30.08.2018
An artificial intelligence predicts therapeutic response in patients with advanced rectal cancer treated with preoperative radiochemotherapy
The digestive oncology teams from European Georges Pompidou Hospital, Cochin and Ambroise Paré AP-HP, and laboratory “Information Sciences and personalized medicine” of 1138 Unit Research Center Cordeliers INSERM and Paris-Descartes University, have developed an artificial intelligence system that predict therapeutic response to preoperative chemoradiotherapy in patients monitored for rectal cancer. The work, coordinated by Dr. Jean-Emmanuel Bibault of oncology radiotherapy European Hospital Georges Pompidou AP-HP, would propose a conservative treatment rather than full rectal ablation patients complete therapeutic response.
- Press releases - 30.08.2018
Metformin Improves Motor Skills in Patients with Steinert Myotonic Dystrophy, the Most Common Adult Neuromuscular Disease
Inserm researchers at I-Stem – the Institute for Stem Cell Therapy and Exploration of Monogenic Diseases – report encouraging results with metformin, a known diabetes drug, for the symptomatic treatment of Steinert myotonic dystrophy. A phase II trial conducted in 40 patients at Henri-Mondor Hospital AP-HP has shown that, after 48 weeks of treatment at the highest dose, patients treated with metformin (versus placebo) gain in motor skills and recover a more stable gait. The results of this trial, which received 1.5 million euros in funding from AFM-Téléthon, are published today in Brain.
- Press releases - 27.08.2018
Predicting The Response To Immunotherapy Using Artificial Intelligence
A study published in The Lancet Oncology establishes for the first time that artificial intelligence can process medical images to extract biological and clinical information. By designing an algorithm and developing it to analyse CT scan images, medical researchers at Gustave Roussy, CentraleSupélec, Inserm, Paris-Sud University and TheraPanacea (spin-off from CentraleSupélec specialising in artificial intelligence in oncology-radiotherapy and precision medicine) have created a so-called radiomic signature. This signature defines the level of lymphocyte infiltration of a tumour and provides a predictive score for the efficacy of immunotherapy in the patient.
- Press releases - 27.08.2018
Mechanism of Repression: Can a Person’s Memories be Altered Without Their Knowledge?
In recent years, the cognitive neurosciences have shown that it is possible to use conscious effort to alter memories. Researchers from the Inserm Center for Psychiatry and Neuroscience, Sainte Anne Hospital and Université Paris Descartes now show that it is possible to unconsciously alter memories. This experimental demonstration of the unconscious manipulation of memories, which is similar to the psychoanalytical concept of repression, has been published in the journal Cognition.