Author Archives: Priscille Rivière

Wednesday 20th February 2019

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Monday 18th February 2019

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Gene therapy durably reverses congenital deafness in mice

In collaboration with the universities of Miami, Columbia and San Francisco, scientists from the Institut Pasteur, Inserm, CNRS, Collège de France, Sorbonne University and the University of Clermont Auvergne have managed to restore hearing in an adult mouse model of DFNB9 deafness – a hearing disorder that represents one of the most frequent cases of congenital genetic deafness. Individuals with DFNB9 deafness are profoundly deaf as they are deficient in the gene coding for otoferlin, a protein which is essential for transmitting sound information at the auditory sensory cell synapses. By carrying out an intracochlear injection of this gene in an adult DFNB9 mouse model, the scientists successfully restored auditory synapse function and hearing thresholds to a near-normal level. These findings, published in the journal PNAS, open up new avenues for future gene therapy trials in patients with DFNB9.

Posted in Press releases, Genetics, genomics and bioinformatics, Neurosciences, cognitives sciences, neurology and psychiatry | Comments closed

Monday 18th February 2019

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Friday 15th February 2019

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Physical activity, prevention and treatment of chronic diseases – A collective expert review by Inserm

Inserm was tasked by the French Ministry of Sports with producing a collective expert review in order to take stock of scientific knowledge and to analyze, within the scope of chronic diseases, the impact of physical activity and its place in the care pathway. This review is based on a critical analysis of the international scientific literature made by a multidisciplinary group of thirteen researchers with expertise in various fields relating to chronic diseases, from sports medicine to psychosociology.

Posted in Press releases, Public health | Comments closed

Wednesday 13th February 2019

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Wednesday 13th February 2019

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Tuesday 12th February 2019

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Direct-acting antivirals: confirmation of their short-term clinical efficacy in “real life”

A study published in The Lanceton 11 february 2019shows that direct-acting antivirals have short-term clinical benefits in the treatment of hepatitisCvirusinfection. These results come from ANRS-funded interdisciplinary research conducted byclinicians,hepatologists, and epidemiologistsof theInserm, SorbonneUniversityand AP-HPandcoordinatedby ProfessorsFabrice CarratandStanislas Pol,and Dr Hélène Fontaine,1in9895 patientsof the ANRS CO 22 HEPATHERnational cohortrecruitedin 32 centers in France.

Posted in Press releases, Immunology, inflammation, infectiology and microbiology | Tagged | Comments closed
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