B-cells and tertiary lymphoid structures contribute to immune checkpoint blockade response, Nature in press.
Beth A. Helmink1*, MD PhD; Sangeetha M. Reddy2*, MD MSci; Jianjun Gao3, MD PhD*; Shaojun Zhang4*, PhD.; Rafet Basar5, MD PhD; Rohit Thakur1, PhD; Keren Yizhak6, PhD; Moshe Sade-Feldman6,7, PhD; Jorge Blando8, DVM; Guangchun Han4; Vancheswaran Gopalakrishnan1, PhD; Yuanxin Xi10, PhD; Hao Zhao8, PhD; Wenbin Liu8; Valerie LeBleu9, PhD; Fernanda G. Kugeratsk9, PhD; Hussein A. Tawbi11, MD PhD; Rodabe N. Amaria11, MD; Sapna Patel11, MD; Michael A. Davies11, MD PhD; Patrick Hwu11, MD; Jeffrey E. Lee1, MD; Jeffrey E. Gershenwald1, MD; Anthony Lucci1, MD; Reetakshi Arora4, PhD; Scott Woodman11, MD PhD; Emily Z. Keung1, MD; Pierre-Olivier Gaudreau1, MD; Alexandre Reuben12, PhD; Christine N. Spencer13, PhD; Alex P. Cogdill1, MEng; Elizabeth M. Burton1, MBA; Lauren E. Haydu1, PhD; Alexander J. Lazar4,14,15, MD PhD; Roberta Zapassodi16, PhD; Courtney W. Hudgens14, BS; Deborah A. Ledesma14, PhD; SuFey Ong17, PhD; Michael Bailey17, PhD; Sarah Warren, PhD; Disha Rao17, MS; Oscar Krijgsman18, PhD; Elisa A. Rozeman18, MD; Daniel Peeper18, PhD; Christian U. Blank18, MD PhD; Ton N. Schumacher18, PhD; Lisa H. Butterfield19, PhD; Raghu Kalluri9, MD PhD; James Allison8, PhD; Florent Petitprez, PhD20,21,22; Wolf Herman Fridman, MD PhD20,21; Catherine Sautes-Fridman, PhD20,21; Nir Hacohen6,8, PhD; MD PhD; Katayoun Rezvani5,≠, MD PhD; Michael T. Tetzlaff14,15,≠, Padmanee Sharma3,8,≠, MD PhD; Linghua Wang4,≠, PhD; Jennifer A. Wargo1,4,≠, MD MMSc. 1 Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center 2 Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center 3 Department of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center 4 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center 5 Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center 6 Department of Medicine, Massachusetts General Hospital Cancer Center 7 Broad Institute of the Massachusetts Institute of Technology 8 Department of Immunology, The University of Texas MD Anderson Cancer Center 9 Department of Cancer Biology, The University of Texas MD Anderson Cancer Center 10 Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center 11 Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center 12 Department of Thoracic / Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center 13 Parker Institute for Cancer Immunotherapy 14 Department of Pathology, The University of Texas MD Anderson Cancer Center 15 Department of Translational and Molecular Pathology, The University of Texas MD Anderson Cancer Center 16 Immunology Program, Sloan Ketterin Institute, Memorial Sloan Kettering Cancer Center. 17 Nanostring Technologies, Seattle, WA 18 Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute 19 Departments of Medicine, Surgery, Immunology and Clinical and Translational Science, University of Pittsburgh 20 INSERM, UMR_S 1138, Cordeliers Research Center, Team Cancer, immune control and escape, Paris, France 21 University Paris Descartes Paris 5, Sorbonne Paris Cite, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France 22 Programme Cartes d’Identité des Tumeurs, Ligue Nationale Contre le Cancer, Paris, France *Contributed equally ≠ Shared senior authorship
Nature : https://doi.org/10.1038/s41586-019-1922-8B-cells and tertiary lymphoid structures contribute to immune checkpoint blockade response, Nature in press. Beth A. Helmink1*, MD PhD; Sangeetha M. Reddy2*, MD MSci; Jianjun Gao3, MD PhD*; Shaojun Zhang4*, PhD.; Rafet Basar5, MD PhD; Rohit Thakur1, PhD; Keren Yizhak6, PhD; Moshe Sade-Feldman6,7, PhD; Jorge Blando8, DVM; Guangchun Han4; Vancheswaran Gopalakrishnan1, PhD; Yuanxin Xi10, PhD; Hao Zhao8, PhD; Wenbin Liu8; Valerie LeBleu9, PhD; Fernanda G. Kugeratsk9, PhD; Hussein A. Tawbi11, MD PhD; Rodabe N. Amaria11, MD; Sapna Patel11, MD; Michael A. Davies11, MD PhD; Patrick Hwu11, MD; Jeffrey E. Lee1, MD; Jeffrey E. Gershenwald1, MD; Anthony Lucci1, MD; Reetakshi Arora4, PhD; Scott Woodman11, MD PhD; Emily Z. Keung1, MD; Pierre-Olivier Gaudreau1, MD; Alexandre Reuben12, PhD; Christine N. Spencer13, PhD; Alex P. Cogdill1, MEng; Elizabeth M. Burton1, MBA; Lauren E. Haydu1, PhD; Alexander J. Lazar4,14,15, MD PhD; Roberta Zapassodi16, PhD; Courtney W. Hudgens14, BS; Deborah A. Ledesma14, PhD; SuFey Ong17, PhD; Michael Bailey17, PhD; Sarah Warren, PhD; Disha Rao17, MS; Oscar Krijgsman18, PhD; Elisa A. Rozeman18, MD; Daniel Peeper18, PhD; Christian U. Blank18, MD PhD; Ton N. Schumacher18, PhD; Lisa H. Butterfield19, PhD; Raghu Kalluri9, MD PhD; James Allison8, PhD; Florent Petitprez, PhD20,21,22; Wolf Herman Fridman, MD PhD20,21; Catherine Sautes-Fridman, PhD20,21; Nir Hacohen6,8, PhD; MD PhD; Katayoun Rezvani5,≠, MD PhD; Michael T. Tetzlaff14,15,≠, Padmanee Sharma3,8,≠, MD PhD; Linghua Wang4,≠, PhD; Jennifer A. Wargo1,4,≠, MD MMSc. 1 Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center 2 Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center 3 Department of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center 4 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center 5 Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center 6 Department of Medicine, Massachusetts General Hospital Cancer Center 7 Broad Institute of the Massachusetts Institute of Technology 8 Department of Immunology, The University of Texas MD Anderson Cancer Center 9 Department of Cancer Biology, The University of Texas MD Anderson Cancer Center 10 Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center 11 Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center 12 Department of Thoracic / Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center 13 Parker Institute for Cancer Immunotherapy 14 Department of Pathology, The University of Texas MD Anderson Cancer Center 15 Department of Translational and Molecular Pathology, The University of Texas MD Anderson Cancer Center 16 Immunology Program, Sloan Ketterin Institute, Memorial Sloan Kettering Cancer Center. 17 Nanostring Technologies, Seattle, WA 18 Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute 19 Departments of Medicine, Surgery, Immunology and Clinical and Translational Science, University of Pittsburgh 20 INSERM, UMR_S 1138, Cordeliers Research Center, Team Cancer, immune control and escape, Paris, France 21 University Paris Descartes Paris 5, Sorbonne Paris Cite, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France 22 Programme Cartes d’Identité des Tumeurs, Ligue Nationale Contre le Cancer, Paris, France *Contributed equally ≠ Shared senior authorship Nature : https://doi.org/10.1038/s41586-019-1922-8