Left to right : Pr Elisabeth Tournier-Lasserve, Pr Hugues Chabriat, Pr Marie-Germaine Bousser, Dr Anne Joutel
Awarded by the Danish Lundbeck Foundation, the “Brain Prize” is a major international award for scientific importance of their research in neuroscience. It has a total of one million euros.
He puts this year in honor of the work begun there nearly forty years by four French scientists on CADASIL, a hereditary cerebrovascular disease, which causes migraine attacks, stroke and cognitive decline. Today is the genetic disease of small cerebral vessels most frequently diagnosed.
The four winners of the French “Brain Prize 2019” are:
> Professor Elisabeth Tournier-Lasserve , head of the hospital neurovascular genetics department Lariboisière AP-HP, medical genetics professor at Paris Diderot University and head of the research team “cerebrovascular diseases, genomics , imaging and personalized medicine “within the unit Paris Diderot – Inserm 1141” NeuroDiderot “.
> Professor Hugh Chabriat , head of the neurology department of the hospital Lariboisière AP-HP, coordinator of the reference center for rare vascular diseases of the brain and the eye (CERVCO), professor of neurology at the University Paris Diderot and researcher at the research team “cerebrovascular diseases, genomics, imaging and personalized medicine” in the unit of Paris-Diderot – Inserm 1141 “NeuroDiderot”. Prof. Chabriat also co-coordinates the University Hospital Department (DHU) neurovasc Sorbonne Paris Cité.
> Professor Marie-Germaine Bousser , former head of the neurology department at the hospital Lariboisière AP-HP and emeritus professor of neurology at the University of Paris Diderot.
> Dr. Anne Joutel, Research Director Inserm, director of the team “pathophysiological mechanisms of diseases of the small cerebral vessels” at the Institute of Psychiatry and Neurosciences Paris Descartes – UMR1266 Inserm and professor in the pharmacology department University of Vermont (USA).
The discovery of CADASIL has allowed the development of diagnostic tests and the development of mouse models of the disease, essential to understand the mechanisms of brain damage and the development of therapeutic. The identification and clinical and preclinical study of this disease are also a major step to identify and better understand other diseases of cerebral vessels.
Researchers at CNRS, Université Côte d’Azur and Inserm have demonstrated a new mechanism related to the onset of migraine. In fact, they found how a mutation, causes dysfunction in a protein which inhibits neuronal electrical activity, induces migraines. These results, published in ...