A French consortium of clinicians and biologists has proposed a molecular classification of colon cancers into six sub-types.
A national multicentric consortium of clinicians, biologists and researchers performed a genomic study as part of the CIT programme (Cartes d’Identité des Tumeurs® [Tumour Identity Cards]) of the Ligue contre le Cancer. The study included tumours from 566 patients suffering from colon cancer, the results of which were published in the international journal PLOS MEDECINE.
In analysing a transcriptome of this cohort that is perfectly described clinically and pathologically, the consortium produced a robust classification into six molecular sub-types that were well-defined in terms of changes to the genome and signalling routes associated with a gene expression signature.
These six sub-types are correlated to separate prognoses. The classification was validated using an independent series of 1,181 colon cancers.
It is planned to apply the signature of each sub-type to other series of colon tumours with the aim of obtaining a routinely transferable diagnostic tool so as to improve the prognosis and to guide treatment.
crédit : ©Inserm
Pr. Pierre Laurent-Puig UMRS775 Bases Moléculaires de la réponse aux xénobiotiques rf.setracsedsirap@giuptnerual.erreiP 01 42 86 20 81 Dr. Aurélien de Reyniès Programme Cartes d’Identité des Tumeurs, Ligue contre le cancer ten.recnac-eugil@aseinyer 01 53 55 25 12
“Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic Value”
L Marisa, A de Reyniès, A Duval, J Selves, MP Gaub, L Vescovo, MC Etienne-Grimaldi, R Schiappa, D Guenot, M Ayadi, S Kirzin, M Chazal, JF Fléjou, D Benchimol, A Berger, A Lagarde, E Pencreach, F Piard, D Elias, Y Parc, S Olschwang, G Milano, P Laurent-Puig,, V Boige
PLOS MEDICINE, 22 mai 2013