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Observing the brain of moving animals

Such is the brain’s complexity that it is a particularly difficult organ to examine despite technological progress in this area. While electroencephalograms (EEG) and optical techniques can be used to record neurone activity in mobile animals, it is only possible to examine certain areas of the brain due to the size of the electrodes and light diffraction. Alternatively, functional ultrasound imaging (fUS) and magnetic resonance imaging (MRI) can be used to record variations in blood flow in the brain. Since active neurones need to be well-supplied with blood, blood flow in a given area reflects neurone activity in this area. However, these techniques require subjects to be completely immobile.Imagerie électro-encéphalographique

Electroencephalographic image. © Inserm/CRICM – Plateau MEG/EEG – Inserm U975

Two teams led by Ivan Cohen from Inserm Unit 1130 “Neuroscience Paris Seine” and Mickaël Tanter from Inserm Unit 979 “Wave physics for medicine” at the Langevin Institute (ESPCI/CNRS) have improved the fUS method to make it portable and usable with conscious and mobile rats at the same time as an EEG.

In order to demonstrate the benefits of this new method for pathological applications, the researchers looked at cerebral mechanisms in rats that reproduce epileptic seizures.

Thanks to this cutting-edge technology, we have precisely observed changes in blood flow which are precursors of epileptic seizure onset“, explains Inserm Research Fellow Ivan Cohen.

A study of cerebral mechanisms of mobile animals offers multiple opportunities for understanding behaviour and neurological conditions by mapping the regions of the brain associated with them. In particular, this technology will allow us to combine neurological and vascular data that play a key role in conditions such as dementia, strokes, epilepsy and Alzheimer’s disease.

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Researcher Contact

Ivan Cohen
Chargé de recherche Inserm
Unité Inserm 1130 ” Neuroscience Paris Seine” (INSERM/CNRS/UPMC)
+ 33 (0) 1 44 27 25 91 / + 33 (0) 6 69 30 84 50 

Mickaël Tanter
Directeur de recherche Inserm
Unité Inserm 979 ” Physique des ondes pour la médecine” (ESPCI/CNRS/INSERM/UPMC/Paris VII)
+ 33 (0) 1 80 96 30 68

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EEG and functional ultrasound imaging in mobile rats Lim-Anna Sieu1,2, Antoine Bergel1,3, Elodie Tiran4, Thomas Deffieux4, Mathieu Pernot4, Jean-Luc Gennisson4, Mickaël Tanter4 & Ivan Cohen1 1INSERM U1130, CNRS UMR 8246, University Pierre et Marie Curie UMCR18, Paris, France. 2Institut des Neurosciences Translationnelles de Paris, Paris, France. 3Ecole Doctorale Frontières du Vivant (FdV), Programme Bettencourt, Universite´ Paris Diderot, Sorbonne Paris Cite´, Paris, France. 4Institut Langevin, Ecole Supérieure de Physique et de Chimie Industrielles de la ville de Paris ParisTech, Paris Sciences et Lettres Research University, CNRS UMR 7587, INSERM U979, Paris, France. Nature Methods, 3 août 2015