The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function
Vânia L. Batalha1,11, Diana G. Ferreira1,2,3, Joana E. Coelho1, Jorge S.Valadas1,#, Rui Gomes1,4, Mariana Temido-Ferreira1, Tatiana Shmidt7, Younis Baqi9,10, Luc Buée6, Christa E. Müller9, Malika Hamdane6, Tiago F.Outeiro2,14,15, Michael Bader7,8,13,Sebastiaan H. Meijsing11, Ghazaleh Sadri-Vakili12, David Blum6,* and Luísa V. Lopes1,*
1Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Universidade de Lisboa,
Portugal
2Department of Neurodegeneration and Restorative Research, University Medical Center
Göttingen,
3Instituto de Farmacologia e Terapêutica, Faculdade de Medicina do Porto, Universidade do
Porto, Portugal
4Faculdade de Ciências de Lisboa, Universidade de Lisboa, Portugal
5Laboratory of Neurophysiology, ULB Neuroscience Institute, Université Libre de Bruxelles
(ULB), Brussels, Belgium
6 Inserm, UMR-S 1172, Alzheimer & Tauopathies, Centre de Recherche Jean-Pierre Aubert,
Lille, Univ. Lille, Faculté de Médecine, Lille F-59045, France.
7Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany
8Charité-University Medicine Berlin, Germany
9PharmaCenter Bonn, Pharmazeutische Chemie I, Pharmazeutisches Institut, University of
Bonn, Bonn, Germany
10 Department of Chemistry, Faculty of Science, Sultan Qaboos University, Muscat, Oman
11Max Planck Institute for Molecular Genetics, Berlin,Germany
12MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital,
Boston, MA, United States of America.
13Institute of Biology, University of Lübeck, Germany
14Max Plank Institute for Experimental Medicine, Goettingen, Germany
15CEDOC, Centro de Estudos de Doenças Crónicas, Lisbon, Portugal
Scientific Reports (Springer Nature), 11 aout 2016
www.dx.doi.org/10.1038/srep31493