Pour combattre la désinformation et rendre la parole à la science, l’Inserm lance sa nouvelle série destinée à valoriser la parole scientifique: Canal Détox, des vidéos au format court et des textes visant à décoder l’actualité et à vérifier les informations qui circulent dans le domaine des sciences de la vie et de la santé.
Asymmetry plays a major role in biology at every scale: think of DNA spirals, the fact that the human heart is positioned on the left, our preference to use our left or right hand … A team from the Institute of biology Valrose (CNRS/Inserm/Université Côte d’Azur), in collaboration with colleagues from the University of Pennsylvania, has shown how a single protein induces a spiral motion in another molecule. Through a domino effect, this causes cells, organs, and indeed the entire body to twist, triggering lateralized behaviour. This research is published in the journal Science on November 23, 2018.
Why are some depressed patients more or less totally resistant to the most commonly-prescribed antidepressants? This question was addressed by researchers from Inserm
A joint study conducted by Inserm researchers from IBENS (Institute of Biology of the Ecole Normale Supérieure – Inserm/CNRS/ENS Paris) in Paris and researchers from SIgN (Singapore Immunology Network, A*STAR) in Singapore has revealed a hitherto undiscovered role played by the microbiota on immune cells in the brain, occurring from the fetal stage. These cells, known as microglia, play a key role in brain development and function, and are affected in different ways by changes in the microbiota in male and female mice at different stages of their lives. The results of this research have been published in Cell.
Could a common mushroom help fight certain genetic diseases? Although surprising, this is indeed the new discovery made by French scientists from Inserm, the French National Museum of Natural History, the CNRS, Université de Lille, and the Institut Pasteur de Lille. By examining numerous extracts, the scientists thus evidenced that the mushroom, Lepista inversa, acted significantly on three isolated cell lines taken from patients with cystic fibrosis. This research was published in .Plos One
After 40 years of research, researchers at the CEA, the CNRS, the University of Grenoble-Alps, the University of Montpellier and the Inserm have finally identified the enzyme responsible for the tubulin cycle. Surprisingly, it is not one enzyme but two which control the cycle of this essential component of the cytoskeletal structure. This work opens up new prospects for the improved understanding of the role of tubulin, changes in the cycle of which are associated with cancers, cardiac diseases and neural disorders. These results were published on 16th November 2017 in the review Science.
On July 13, 2017, the journal Lancet Neurology published the results of a gene therapy trial conducted in four children with Sanfilippo type B syndrome (also known as MPS IIIB). This trial is the achievement of a two-decade partnership with financial support of AFM-Téléthon and the cooperation of the charity "Vaincre les Maladies Lysosomales" (VML). After monitoring of the treated children for 30 months, Dr. Jean-Michel Heard, from the Institut Pasteur and Inserm, and Professors Marc Tardieu and Michel Zérah, from the Paris public hospital administration (AP-HP) and the Paris-Sud and Paris Descartes Universities, conclude that the treatment was well tolerated and associated with neurocognitive benefits for the patients.
Une équipe de jeunes chercheurs dirigée par Guillaume Montagnac, chargé de recherche Inserm à Gustave Roussy, en collaboration avec l’Institut Curie et l’Institut de Myologie, a découvert un nouveau mécanisme qui aide les cellules à migrer. La cellule forme à la surface de sa membrane de multiples petites pinces qui l’aident à s’accrocher pour mieux progresser le long des fibres présentes à l’extérieur de la cellule. Ce mécanisme permet de mieux comprendre comment une cellule s’échappe de la masse tumorale et se déplace dans le corps pour aller former un nouveau foyer.
It is known that IGF-1 (insulin-like growth factor) is needed for development and also plays a role throughout the body’s life. Previously, the team led by Martin Holzenberger (Inserm/UPMC Unit 938, Saint-Antoine Research Center) has shown that this hormone is involved in longevity and in Alzheimer’s disease. The team has recently conducted further research on IGF-1 and the response of neurons to this kind of neurodegeneration. These new results have been published in Brain.
A study conducted by Inserm researchers at the Research Institute for Environmental and Occupational Health (Irset) has shown that natural selection has "purged" our bodies of many of the traces of our ancient Neanderthal and Denisovan cousins in the genes responsible for the genetic mixing essential to reproduction. The researchers have shown that the genes expressed during meiosis in the cells that produce gametes (reproductive cells) are strongly deficient in genetic variations of Neanderthal origin that were the result of the interbreeding between Homo sapiens and Homo neanderthalensis. These results have been published in Molecular Biology and Evolution.