Pour combattre la désinformation et rendre la parole à la science, l’Inserm lance sa nouvelle série destinée à valoriser la parole scientifique: Canal Détox, des vidéos au format court et des textes visant à décoder l’actualité et à vérifier les informations qui circulent dans le domaine des sciences de la vie et de la santé.
An international collaborative study coordinated by Frédéric Laumonnier (Unit 930 “Imaging and Brain” Inserm/University of Tours) and Yann Hérault of the Institute of Genetics and Molecular and Cellular Biology (Inserm/ CNRS/ University of Strasbourg) provides new and original findings on the pathophysiological role of the contact areas between neurons in certain brain disorders. The study reveals that mutation of one of the genes involved in intellectual disability and autism spectrum disorder leads to dysfunction of the synapses, which are essential for neuronal communication.
A new study conducted by Inserm researchers at Irset (Institute of Research in Environmental and Occupational Health) shows that ibuprofen is liable to cause disruptions in the hormone system in the human foetal testis, with possible implications for the development of the male urogenital tract. This drug suppresses the production of various testicular hormones, including testosterone, which controls the primary and secondary sex characteristics and the descent of the testes. These effects are obtained at doses similar to the standard dosage. These results are published in Scientific Reports.
Some cancer cells are resistant to treatment and persist. If they are capable of proliferating again, even a very small number of these cells may be enough to reconstitute a tumour after or despite treatment. Various approaches to eliminate these “cancer stem cells” (CSCs) have been tried in recent years: targeted therapies, vaccination and tumour starvation. In an article published in the journal Cell Reports, Christophe Ginestier, Inserm Research Fellow at the Cancer Research Center of Marseille (CRCM, Aix-Marseille University/CNRS/Institut Paoli-Calmettes), and his collaborators identify a specific RNA molecule that plays the role of a molecular switch that can “turn off” or “turn on” CSC proliferation in breast cancers.
Rénald Delanoue, Inserm Researcher, and his colleagues at the Institute of Biology Valrose in Nice (Inserm-CNRS-Université Côte d’Azur) have identified the missing links in the process that regulates the size of an organism based on the richness of its diet. Their research was conducted on Drosophila, an insect that seems very distant from humans, but the study of which has nonetheless enabled many advances in biomedical research. This work is published in the 30 September 2016 issue of the journal Science.
An international team, including researchers in France at Inserm, CNRS and the University of Strasbourg, brought together at IGBMC is lifting the veil on the molecular mechanisms causing heart dysfunctions in myotonic dystrophy, a genetic disease affecting one person in 8,000. This new study, published this week in Nature Communications, could contribute to discovering a treatment.
Researchers at Inserm Unit 1194, “Montpellier Cancer Research Institute” (Inserm/University of Montpellier/Montpellier Regional Cancer Institute) have confirmed the value of a new test to identify cancer patients who will be free of sequelae following radiotherapy. This test, conducted on a blood sample taken from 500 breast cancer patients, treated in 10 centres in France, and monitored for 3 years, showed that women with a high rate of radiation-induced lymphocyte apoptosis (RILA) had a very low rate of late breast fibrosis. These results, which are published in EBioMedicine, suggest that personalisation of curative intent radiotherapy could be considered, with tailoring of the radiation dose delivered to the patient and the radiotherapy technique employed.
The first embryonic division, which follows gamete fusion (oocyte and spermatozoon), starts the development of a new individual, the genesis of a functional adult body. This division is symmetric in the one-cell embryo stage (also known as the zygote); it leads to the formation of two daughter cells of identical size. Conversely, it is asymmetric in the oocyte, which has the same size and shape as the zygote. Why? What directs the zygote to divide symmetrically, while the oocyte divides asymmetrically during meiosis? Such are the questions pondered by Marie-Emilie Terret, a researcher at Inserm, and Marie-Hélène Verlhac, a researcher at CNRS and director of the Asymmetric Divisions in Oocytes team at the Center for Interdisciplinary Research in Biology (CIRB; Inserm/CNRS/Collège de France).
researchers from Maria-Elena Torres-Padilla’s team have pushed the limits of science even further. They managed to obtain totipotent cells with the same characteristics as those of the earliest embryonic stages and with even more interesting properties.
Researchers at Inserm and Paris Descartes University have just taken an important step in research on stem cells and dental repair. They have managed to isolate dental stem cell lines and to describe the natural mechanism by which they repair lesions in the teeth.