Category Archives: Immunology, inflammation, infectiology and microbiology

Resident and recruited macrophages orchestrate the liver’s defense against infection

Scientists from the Institut Pasteur, Inserm and Paris Descartes – Sorbonne Paris Cité University (Biology of Infections Unit, Inserm U1117, directed by Marc Lecuit) have demonstrated that liver-resident macrophages are rapidly killed by the pathogenic bacterium Listeria monocytogenes. This early death triggers the recruitment of macrophages from the bloodstream to the liver. These macrophages start by bringing the bacterial infection under control; then, in an unexpected development, they actually replace the liver-resident macrophages that have been killed by the infection.

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A microbiota bacterium protects the large intestine from inflammation

The microbiota, which is the term used to describe all micro-organisms living in the mucous membranes, is vital for our health and affects our development, metabolism, immune system etc. However, most of the mechanisms which allow it to play this important role have yet to be discovered. Researchers in Inserm Unit 892 “Nantes-Angers regional cancer research centre” have recently identified one of the mechanisms by which the microbiota enables our immune system to prevent inflammation of the large intestine. Their findings will be published on the Plos Biology website on 9 April.

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Europe supports stem cell research for the treatment of diabetes

The HumEn project aims to develop insulin-producing cells as a future cell replacement therapy for diabetes.

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Regulatory T cells, ensuring a good immune memory

In this new research, published in the Science review, the team of researchers directed by Sebastian Amigorena (Institut Curie / Inserm U932 Immunity and Cancer unit) demonstrates that the regulatory T cells are also important during immune responses to external antigens, i.e. during infection.

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