Category Archives: Public health

Repurposing Drugs to Fight the Flu: a Phase 2 Clinical Trial for FLUNEXT

L’équipe VirPath du CIRI, en collaboration avec le laboratoire du Dr Guy Boivin (chaire de recherche du Canada sur les virus émergents, a développé et validé une stratégie innovante qui consiste à identifier et exploiter directement des échantillons infectieux prélevés cliniquement, afin de sélectionner et d’utiliser des médicaments déjà commercialisés pour soigner d’autres virus (on parle alors de « repositionnement de médicaments »). Ce programme a été financé par l’Inserm, la DGOS, l’Agence National de la Recherche, la Région Auvergne Rhône-Alpes, l’Université Claude Bernard et l’Université Laval.

Drug overconsumption in pregnant women in France

Pregnancy is a sensitive time, particularly in the first months. Pregnant women are therefore strongly advised to limit their use of medicines, as some of their effects are yet poorly known. Nevertheless, a recent study conducted by Inserm researchers reveals that pregnant French women are among the largest consumers of drugs worldwide with around ten medicines prescribed during pregnancy. A rate which remained stable throughout the period analyzed (2011-2014).

Benefits of Unit-Dose Antibiotic Sale

Between November 2014 and November 2015, a study conducted by Inserm (Unit 912 SESSTIM – Economic and Social Sciences, Health Systems and Medical Informatics), Université Aix-Marseille, IRD, CNRS and the PACA Regional Health Observatory, trialed the unit-dose dispensing of certain antibiotics across four regions in France. Out of 100 volunteer pharmacies, 75 pharmacies were randomly selected to offer unit-dose dispensing of treatment to patients with a prescription stating one or more of the 14 antibiotics concerned. The results of this trial, published in PLos ONE on September 19, 2017, are as follows:

13/11 attacks: young people deeply marked

One year after the 13 November attacks, the survey “Conditions de vie et Aspirations” (Living Conditions and Aspirations) by CRÉDOC (Research Centre for the Study and Monitoring of Living Standards), part of the 13 Novembre programme initiated by Inserm, CNRS and héSam Université, reports on the strong impact of the attacks on the French population, particularly the young.

Centenarian athletes: flawless performances?

When the upcoming 2016 Summer Olympics are held, some centenarian athletes will be able to witness this competition, 80 years after their own participation for some of them. An Inserm study conducted by researchers from Unit 1093, “Cognition, Motor Activity and Sensorimotor Plasticity,” at the University of Burgundy, analysed the records of centenarian athletes in various disciplines compared with world records, for all age categories combined. The record of centenarian cyclist Robert Marchand, who cycled nearly 27 kilometres in an hour, appears to be the most impressive, since the reduction in his performance is quite limited given his age.

Academic Doping: Psychostimulant Use Among Medical Students

Under severe pressure owing to an intense workload, medical students are attempting to boost their performance by any means. An Inserm study has revealed possible psychostimulant use among a third of these students.

Final results of JIKI trial

The final conclusions of the JIKI clinical trial, testing the efficacy of favipiravir in reducing mortality in individuals infected by Ebola virus in Guinea, are published in PLoS Medicine this week. This work was carried out under the leadership of Prof. Denis Malvy, Inserm, with the help of a large team of international researchers. Although the conclusions are qualified, they have nonetheless made it possible to collect data and benchmarks that will enable researchers to base their future trials on robust hypotheses and criteria.

Seniors: Developing one’s balance and muscle strength is effective

Following a programme of physical exercise based on balance and building muscle strength reduces the risk of injury from falls by nearly 20% in women aged over 75 years.

In Paris, inhabitants of disadvantaged areas are more vulnerable to the effects of atmospheric pollution

Researchers from Inserm have analysed the causes of 79,107 deaths of Paris inhabitants aged over 35 years between 2004 and 2009. Their objective was to explore whether or not a combination of neighbourhood characteristics (socioeconomic profile and daily exposure to pollution) modified the risk of mortality during episodes of pollution such as those experienced in France during the heatwave of early summer 2015.

In 40 years the French have adapted their behaviour to climate change

Are we getting used to rising temperatures over the years? This is the question that researchers in the Inserm Unit 1169 team ‘Epigenetics and Environment’ (Inserm/CEA/Paris-South University) are trying to answer.

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