Le cancer du sein est le type de cancer le plus répandu dans le monde et l’une des principales causes de décès chez les femmes. Une étude impliquant des chercheurs de l’Université Paris-Saclay, de l’Inserm et d’INRAE vient d’établir un lien entre le travail de nuit et l’augmentation du risque de cancer, suggérant que la perturbation du rythme circadien pourrait rendre les tumeurs plus agressives.
Une analyse de la cohorte CANTO, réalisée par des médecins-chercheurs de Gustave Roussy, de l’Inserm et de l’université Paris-Saclay, démontre pour la première fois à l’aide d’une mesure biologique que les jeunes femmes qui ne suivent pas leur traitement d’hormonothérapie (tamoxifène) pour le cancer du sein rechutent davantage.
Until now considered highly promising in the fight against aging, the therapeutic strategy of eliminating the senescent cells that accumulate in the body is being challenged by the team of Dmitry Bulavin, Inserm researcher at the Institute for Research on Cancer and Aging of Nice (Inserm/CNRS/Université Côte d’Azur).
An ordinary edible mushroom could be a game-changer when it comes to the treatment of rare genetic diseases. These affect hundreds of millions of people worldwide who often find themselves powerless in the absence of effective therapy. A team of researchers has shown that an active ingredient contained in the Lepista inversa mushroom has repair properties, making it possible to correct certain genetic mutations, known as “nonsense” mutations.
Using in vivo imaging tools, scientists from the Institut Pasteur and Inserm described the spatiotemporal activity of tumor-infiltrating T lymphocytes, both locally and remotely.
Les tumeurs hypophysaires disposent désormais d’une classification moléculaire précise, complète et objective, avec la perspective de mieux prédire et comprendre le comportement de certains sous-types de tumeurs et d’ajuster les traitements.
Une équipe de chercheurs de l’Inserm, au sein de l’Institut de recherche sur le cancer et le vieillissement (Inserm/CNRS/Université Côte d’Azur), a eu l’idée d’utiliser des briques de LEGO® pour concevoir un nouveau système d’étirement permettant de simuler certaines contraintes mécaniques que subissent les cellules au sein de l’organisme.
Does the blood we thought to know so well contain elements that had been undetectable until now? The answer is yes, according to a team of researchers which has revealed the presence of whole functional mitochondria in the blood circulation. These organelles that are responsible for cellular respiration had hitherto only been found outside cells in very specific cases.
Glioblastomas are the most common type of brain tumor, and their prognosis is often highly unfavorable. A collaborative study by Jean-Léon Thomas, Inserm researcher at the Brain & Spine Institute (Inserm/CNRS/Sorbonne Université) and Pitié-Salpêtrière Hospital AP-HP, and Akiko Iwasaki (Department of Immunology, Yale University School of Medicine, USA), has revealed the beneficial role played by the meningeal lymphatic vascular network in treating these tumors – in the short and longer term.
An international team led by Wolf Hervé Fridman with researchers from Inserm, Sorbonne Université and Université de Paris at the Cordeliers Research Center, in collaboration with the French League against cancer and Institut Bergonié, has shown that B cells also play a major role in predicting of patient’s response to immunotherapy. It was previously thought only T cells could be used in this way.