Category Archives: Cancer

Better air quality: what should the target values be for improving health?

To produce a significant reduction in mortality due to fine particulates, their average level should be reduced by at least 3 micrograms per m3 as a yearly average, concludes an interdisciplinary study.

Also posted in Press releases, Public health | Tagged | Comments closed

Human “Jumping Genes” Caught in the Act!

Over the course of evolution, the genomes of most living organisms have grown more complex thanks to transposable elements, a.k.a. “jumping genes,” or DNA fragments that can move and copy themselves from one chromosome location to another. Researchers from Inserm, the CNRS, Université Côte d’Azur, and Université de Montpellier were able to capture these “jumping genes” just after they moved.

Also posted in Molecular and structural bases of living organisms, Press releases | Tagged | Comments closed

Metastatic Lung Cancer: A Targeted Therapy to Improve Treatment Efficacy

When faced with the most aggressive forms of lung cancer, how can the efficacy of chemotherapy be increased? Teams from Inserm, Université Paris Descartes and the Paris public hospitals system AP-HP have maybe hit on a solution. They have developed a targeted therapy which aims to improve the response to platinum salts – the standard chemotherapy used in lung cancer – by neutralizing the activity of a receptor that contributes to its aggressiveness. This research, published in Cancer Letters, shows that in mice this therapy restores the response to chemotherapy and reduces the risk of metastasis by one half to two thirds.

Also posted in Press releases | Tagged | Comments closed

Early Environmental Exposures and Child Respiratory Health: the Exposome Reveals its Preliminary Results

A team of researchers from Inserm, CNRS, Université Grenoble Alpes and Barcelona Institute for Global Health has shown that prenatal and postnatal exposure to various chemical pollutants is linked to decreased respiratory function in children. These results, based on the concept of the exposome (defined as the totality of an individual’s environmental exposures from conception until old age), were obtained as part of the European HELIX project and have been published in The Lancet Planetary Health.

Also posted in Press releases, Europe | Comments closed

(Français) Des techniques synchrotrons révèlent l’action d’une molécule métallo-organique dans des cellules d’une forme agressive du cancer du sein

(Français) Certains types de cancer, comme le cancer du sein type triple négatif, restent réfractaires aux traitements par chimiothérapie. Des scientifiques de l’Inserm, du CNRS, de Sorbonne université, de l’université PSL, de l’Université Grenoble Alpes et de l’ESRF, le synchrotron européen de Grenoble, ont étudié une molécule organométallique, intéressante pour son activité antitumorale. Leurs recherches ont apporté une meilleure compréhension de son mécanisme d’action. Ces résultats sont publiés dans Angewandte Chemie.

Also posted in Press releases | Comments closed

Cancer under pressure: visualizing the activity of the immune system on tumor development

As tumors develop, they evolve genetically. How does the immune system act when faced with tumor cells? How does it exert pressure on the genetic diversity of cancer cells? Scientists from the Institut Pasteur and Inserm used in vivo video techniques and cell-specific staining to visualize the action of immune cells in response to the proliferation of cancer cells. The findings have been published in the journal Science Immunology on November 23, 2018.

Also posted in Cell biology, development and evolution, Press releases, Genetics, genomics and bioinformatics, Immunology, inflammation, infectiology and microbiology, Health technologies | Tagged | Comments closed

A new pathway for modulating anti-tumoral immune response

Researchers from Inserm, CNRS, Paris-Sud University, Gustave Roussy, and Institut Curie have identified a new agent in regulating PD-L1 gene expression: the eIF4F complex, which plays a role in controlling protein synthesis.

Also posted in Press releases | Comments closed

Development of an alternative to bone grafting for edentate patients

Decreased jaw bone volume in edentate patients is the main difficulty which arises when fitting dental implants. Bone grafting is currently the most frequent solution for this problem. However, this method has several disadvantages, such as deterioration of the bone graft over time. Between 2010 and 2015, Pierre Layrolle, Inserm researcher, working with Norwegian and German teams as part of the REBORNE European project, tested an innovative technique for bone augmentation in 11 edentate patients, by combining a biomaterial with stem cells. The results, published in the journal Stem Cell Research & Therapy, demonstrate sufficient growth of viable bone in the treated area to allow implants to be fitted, together with the durable preservation of this bone after fitting dental prostheses.

Also posted in Press releases, Circulation, metabolism, nutrition | Comments closed

Liver Cancer: When the Cell Environment Plays a Role in Tumor Development

Liver cancer is the second most deadly form of cancer worldwide. While the majority of patients develop hepatocellular carcinoma, 10 to 20 % develop the second type of primary liver cancer: intrahepatic cholangiocellular carcinoma – a highly-invasive cancer of the liver bile ducts. And while both these tumor types have some risk factors in common, the number of patients presenting with intrahepatic cholangiocellular carcinoma has seen a marked increase in recent years. A team of researchers led by Prof. Lars Zender from University Hospital Tübingen (Germany), in conjunction with researchers from the National Cancer Institute (Bethesda, United States), Institut Pasteur, Inserm and CNRS, has recently demonstrated that the cell environment, with its dying liver cells, determines the path taken by the tumor cells. These findings were published in Nature on September 12, 2018.

Also posted in Press releases | Tagged | Comments closed

Major advances in the diagnosis and treatment of allograft rejection

Prof. Alexander Loupy, Hospital Necker Children AP-HP and Prof. Carmen Lefaucheur, the Saint-Louis Hospital AP-HP and the University Paris Diderot in the Cardiovascular Research Center (Inserm / Paris Descartes University), showed, in an article published in the journal   New England Journal of Medicine September 20, 2018, the latest advances and applications of artificial intelligence carried out in the field of transplantation, including the diagnosis and the treatment of allograft rejection.

Also posted in Press releases, Immunology, inflammation, infectiology and microbiology | Tagged | Comments closed
RSS Youtube