Category Archives: Cancer

Meningeal Lymphatic Network: A New Avenue in the Treatment of Brain Tumors

Glioblastomas are the most common type of brain tumor, and their prognosis is often highly unfavorable. A collaborative study by Jean-Léon Thomas, Inserm researcher at the Brain & Spine Institute (Inserm/CNRS/Sorbonne Université) and Pitié-Salpêtrière Hospital AP-HP, and Akiko Iwasaki (Department of Immunology, Yale University School of Medicine, USA), has revealed the beneficial role played by the meningeal lymphatic vascular network in treating these tumors – in the short and longer term.

B Cells: New Allies in Sarcoma Immunotherapy?

An international team led by Wolf Hervé Fridman with researchers from Inserm, Sorbonne Université and Université de Paris at the Cordeliers Research Center, in collaboration with the French League against cancer and Institut Bergonié, has shown that B cells also play a major role in predicting of patient’s response to immunotherapy. It was previously thought only T cells could be used in this way.

Une femme sur cinq ne reprend pas le travail un an après la fin des traitements d’un cancer du sein dans la cohorte CANTO

Publiée dans le Journal of Clinical Oncology, une nouvelle analyse de la cohorte CANTO (CANcer TOxicities) identifie les déterminants de la reprise de l’activité professionnelle après un cancer du sein.

Metastasis: When Cancer Cells Hitch a Ride Through the Bloodstream

Imagerie de billes fluorescentes sont filmées à très haute vitesse,

Circulating tumor cells use the blood and lymphatic networks to disseminate within the body, forming metastases distant from the primary tumor. Inserm researcher Jacky Goetz and his Tumor Biomechanics team at the Molecular ImmunoRheumatology laboratory (Inserm/Université de Strasbourg) have helped to show that the flow properties of these biological fluids have a huge influence on the risk of developing metastases.

Towards a Drug to Combat a Severe Intestinal Disease in Children, Immunocompromised Patients

Researchers have recently discovered a new candidate drug to control cryptosporidiosis, a severe intestinal disease in children, immunocompromised patients, and young ruminants. Beyond this disease, their research represents an opportunity to discover new therapeutic avenues for related infections, such as toxoplasmosis and malaria.

A Vaccine to Overcome Immunotherapy Resistance

Researchers have shown that a commercially-available vaccine can overcome resistance to immunotherapy. Their study, published in Science Translational Medicine, shows that not only can gastroenteritis vaccines induce the immunogenic death of cancer cells in vitro, but also that combining them with immunotherapy triggers a potent anti-tumor immune response in vivo – where immunotherapy alone had failed.

Pediatric Cancers: Why Some Forms of Leukemia Only Affect Children

Acute myeloid leukemia (AML) mainly affects children, with the prognosis often being poor despite several decades of research into more effective treatments. A new study explains why some forms of leukemia develop in very young children.

Some Persistent Organic Pollutants Could Increase Breast Cancer Aggressiveness

Photo d'imagerie en microscopie électronique montrant la transformation des cellules mammaires tumorales dans le cancer du sein

Although persistent organic pollutants (POPs) are already suspected to promote breast cancer, there has been little research into how they affect its aggressiveness.

Hormone therapy has a bigger impact than chemotherapy on women’s quality of life

Analysis of the CANTO cohort published in the journal Annals of Oncology will upset received wisdom on the effects that hormone therapy and chemotherapy have on the quality of life in women with breast cancer. Contrary to the commonly held view, 2 years after diagnosis, hormone therapy, a highly effective breast cancer treatment worsens quality of life to a greater extent and for a longer time, especially in menopausal patients. The deleterious effects of chemotherapy are more transient.

Acting on the immune system even before cancer develops may be feasible

Researchers have shown that using immunotherapies at very early stages could potentially help prevent cancer.

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