Category Archives: Covid-19

Study on the role of “ceramides” in infection by SARS-CoV-2 which could constitute a biomarker of severity and a therapeutic target in the management of Covid-19

SARS-CoV-2

Teams of researchers published on October 4, 2021 in the journal Molecular Psychiatry (Nature Publishing Group) a summary of the results of the international literature on the central role that “ ceramides ”, a class of lipids, may play a role in SARS-CoV-2 infection.

Good tolerance of the BNT162b2 vaccine (Pfizer / BioNTech) and good efficacy of the immune response against SARS-CoV-2 variants in patients with systemic lupus

vaccin anti covid

Teams of researchers measured the antibody and cellular responses generated by a messenger RNA vaccine in patients with systemic lupus (LS). This work shows that vaccination is both well tolerated and effective, even against worrying variants. The factors associated with a poor vaccine response in some of these patients have been identified in order to better anticipate who should benefit from reinforced protective measures and / or adapted vaccine protocols.

Inserm Publishes Book on Fake News Making Rigorous and Credible Health Information Accessible to All

As the effects of the COVID-19 crisis continue to make themselves felt, how do we answer the many health questions raised by citizens and make space for scientific information that is useful in everyday life? More motivated than ever to provide robust scientific information to all, Inserm has joined forces with publisher Le Cherche-Midi to deconstruct fake news and preconceived ideas regarding our health.

SARS-CoV-2 : des réponses immunitaires différentes observées dans la muqueuse nasale et dans le sang

Les manifestations cliniques développées à la suite d’une infection par le SARS-CoV-2 sont variables chez les individus, et les mécanismes pouvant expliquer cette variabilité restent encore méconnus. La muqueuse nasale étant un des premiers points d’entrée du virus, des chercheurs de l’Institut Pasteur et de l’Inserm, en collaboration avec l’Hôpital Cochin AP-HP, ont étudié en parallèle les réponses immunitaires dans la muqueuse nasale et dans le sang de personnes infectées par le SARS-CoV-2.

Covid-19 : étude sur l’efficacité de la mémoire immunitaire après vaccination ARNm pour reconnaître les variants du SARS-CoV2

Des chercheurs et chercheuses ont mené des travaux sur la capacité de la mémoire immunitaire générée après vaccination ARNm à reconnaître et neutraliser les variants du SARS-CoV-2.

Covid-19 : identification de cellules immunitaires associées à la survie dans les formes sévères de la maladie

Since the pandemic began, many studies have tried to explain what differentiates the immune response of people with severe forms of COVID-19 resulting in death from that of other patients. In a new study, researchers from Inserm and Sorbonne Université at the Center for Immunology and Infectious Diseases, in collaboration with physician researchers from Paris hospitals group AP-HP, focused on a type of immune response known as the cellular immune response.

Absence d’efficacité du remdesivir chez les patients hospitalisés atteints de Covid-19 et poursuite de l’essai DisCoVeRy pour tester un nouveau médicament antiviral

SARS-CoV-2

The Discovery clinical trial was initially launched in France by Inserm in March 2020, to evaluate several possible treatments for COVID-19. Its European expansion was made possible by the EU-RESPONSE project, funded by the European Commission. Interim analysis of the trial data had led to the recommendation to suspend the recruitment of remdesivir group patients for futility – that is to say due to the very low likelihood of this treatment showing a benefit, even if inclusions were continued.

Rappel vaccinal Covid-19 : une étude de phase 3 avec le vaccin à protéine recombinante de Sanofi et GSK

Vaccination© Adobe Stock

Sorry, this entry is only available in French. Plus de 18 mois après la déclaration de la pandémie, le coronavirus SARS-CoV-2 circule encore activement. Afin d’assurer une protection prolongée contre la Covid-19, les autorités sanitaires françaises se sont prononcées en faveur d’une injection de rappel pour les personnes âgées ou vulnérables. Un nouvel essai mené […]

Covid-19 : les confinements ont eu un impact délétère sur la sévérité du cancer colorectal métastatique

médecin

La pandémie de Covid-19 a très fortement fragilisé la lutte globale contre le cancer. Les confinements successifs ont limité l’accès au soin et ont conduit à une réduction significative du dépistage, du diagnostic et de l’orientation vers les hôpitaux des patients atteints de cancer.

COVID-19: Discovery of a Molecular Signature of Pediatric Myocarditis

enfant masque

Researchers, doctors and teacher-researchers analyzed blood samples from a cohort of 56 pediatric patients admitted to Hôpital Necker Enfants-Malades AP-HP. What they saw was the abnormal expression of several genes associated with the development of severe forms of myocarditis.

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