Category Archives: Immunology, inflammation, infectiology and microbiology

Microbiote : la géographie intestinale influence les interactions entre les bactéries et leurs virus

Les bactéries du microbiote sont soumises à la prédation de leurs virus, les bactériophages, mais une partie d’entre elles peut trouver refuge dans le mucus qui recouvre les tissus de l’intestin, permettant de garder les populations de bactériophages et de bactéries en équilibre.Telles sont les conclusions d’une étude dirigée par Laurent Debarbieux, directeur de recherche et responsable du laboratoire Bactériophage, bactérie, hôte à l’Institut Pasteur avec Luisa De Sordi, maître de conférences Sorbonne Université au Centre de recherche Saint Antoine (Sorbonne Université / Inserm).

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Menstrual Toxic Shock Syndrome: Encourage Proper Tampon Use to Limit Risks

In a study published in March 2020 in the journal EClinical Medicine, Prof. Gérard Lina’s team suggests simple measures to put in place for better tampon use during menstruation.

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COVID-19: Vaccine Research at Inserm

Developing an effective and safe vaccine is one of the priority objectives in the fight to contain the COVID-19 pandemic. At Inserm, a dozen teams are involved in vaccine research projects. In particular, three initiatives have recently been selected by France’s Ministry of Higher Education, Research and Innovation on the advice of the COVID-19 Analysis, Research and Expertise Committee (CARE) and Inserm’s REACTing consortium, in order to receive special support and thus accelerate research.

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Cardiac arrest outside the hospital during the peak of the COVID-19 epidemic: studies highlight pulmonary embolism as the main determinant

Des investigateurs français de l’Institut médico-légal de Paris, de l’Inserm, du service de radiologie de l’hôpital Sainte-Anne/GHU Paris, du département d’anesthésie-réanimation des hôpitaux de l’AP-HP Saint-Louis et Lariboisière, d’Université de Paris, et du CNRS ont fait l’hypothèse que les arrêts cardiaques en dehors de l’hôpital pendant le pic de la pandémie de Covid-19 pourraient être en partie dus à des embolies pulmonaires massives. Le détail de ces travaux a été publié le 28 mai 2020 dans l’European Journal of Heart Failure.

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Inflammatory Bowel Disease: Immune Cells Spearheading the Cure

Inflammations of the intestine affect many patients, often with reduced therapeutic prospects. The role of iron in these inflammatory processes is increasingly well documented, opening up new avenues of treatment. A collaborative study shows that the hormone that regulates iron levels in the body is produced by immune cells during inflammation of the intestine, and that it helps repair damage to the intestinal mucosa.

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Hépatite B : identification d’une nouvelle molécule produite par les cellules hôtes favorisant l’infection

Une équipe de recherche a réussi à identifier une nouvelle molécule favorisant le développement du virus dans les cellules infectées, qui pourrait, à l’avenir, ouvrir de nouvelles perspectives thérapeutiques.

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Covid-19: Publication of a prospective observational study in the journal BMJ in children with hyper-inflammatory syndrome related to Kawasaki disease

characteristics of children and adolescents hospitalized in a context of Kawasaki disease-like syndrome in a COVID-19 epidemic context, with a systemic hyper-inflammatory expression.

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Paris and Its Suburbs: Twice as Many Cardiac Arrests During Lockdown

Indirect consequences of the COVID-19 pandemic on the healthcare system and the management of other diseases are beginning to emerge.

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Blood Stem Cell Immune Memory: A New Research Avenue in COVID-19

Blood stem cells have a surprising ability. In addition to ensuring the continuous renewal of blood cells, they keep track of past infections so that faster and more effective immune responses can be triggered in the future.

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EpiCOV: Population Immune Status Data to Guide Public Decision-Making

Driven by Inserm and the Directorate for Research, Studies, Assessment and Statistics (DREES) of France’s Ministry of Solidarity and Health, in conjunction with their partners (National Institute of Statistics and Economic Studies [INSEE], Public Health Agency, National Center for Scientific Research [CNRS], National Institute for Demographic Studies [INED], Université Paris-Saclay), EpiCOV is a large-scale epidemiological study based on a major statistical survey. It is proposing global and scientifically reliable mapping of population immune status and dynamics across the French territory through the collection of biological samples paired with questionnaires.

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