Category Archives: Immunology, inflammation, infectiology and microbiology

Coronavirus: A Model Estimating Importation Risk to Europe

An Inserm team led by researcher Vittoria Colizza at Pierre Louis Institute of Epidemiology and Public Health (Inserm/Sorbonne Université) has modeled the potential spread of 2019-nCoV in order to orient prevention and surveillance policies. A model which comes with one caveat: derived from research, its purpose is not to make predictions but rather be used as a theoretical tool to aid public decision-making.

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PREVAC-UP: The Partnership for Research on Ebola Vaccination extends follow-up and builds research capacity against deadly disease

PREVAC-UP: The Partnership for Research on Ebola Vaccination extends follow-up and builds research capacity against deadly disease

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A Vaccine Against Chronic Inflammatory Diseases

In animals, a vaccine modifying the composition and function of the gut microbiota provides protection against the onset of chronic inflammatory bowel diseases and certain metabolic disorders, such as diabetes and obesity.

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Influenza : the Reasons for Low Vaccine Coverage Among Pregnant Women

A study reveals that seasonal influenza vaccine coverage remains particularly low among pregnant women in France. Despite risks of severe complications, expectant mothers are often not offered the vaccine during their prenatal monitoring or, if they are, a large majority declines it.

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Towards a Drug to Combat a Severe Intestinal Disease in Children, Immunocompromised Patients

Researchers have recently discovered a new candidate drug to control cryptosporidiosis, a severe intestinal disease in children, immunocompromised patients, and young ruminants. Beyond this disease, their research represents an opportunity to discover new therapeutic avenues for related infections, such as toxoplasmosis and malaria.

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Une piste prometteuse pour la prévention de la sarcopénie et le traitement des maladies neuromusculaires.

En étudiant des muscles jeunes et vieillissants dans un modèle murin, des chercheurs du Centre de recherche en myologie (Sorbonne Université / Inserm) de l’Institut de Myologie sont parvenus à identifier une protéine, la CaVβ1E, qui est à l’origine de l’activation du facteur GDF5. Ce mécanisme permet de prévenir la sarcopénie en maintenant la masse et la force musculaire des souris âgées. L’équipe a identifié la protéine CaVβ1E chez l’homme et montré que son expression est corrélée à la perte de masse musculaire des sujets âgés.

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A Vaccine to Overcome Immunotherapy Resistance

Researchers have shown that a commercially-available vaccine can overcome resistance to immunotherapy. Their study, published in Science Translational Medicine, shows that not only can gastroenteritis vaccines induce the immunogenic death of cancer cells in vitro, but also that combining them with immunotherapy triggers a potent anti-tumor immune response in vivo – where immunotherapy alone had failed.

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Is physical activity always good for the heart?

Physical activity is thought to be our greatest ally in the fight against cardiovascular disease. But there may be significant variations in its protective effects across a range of different situations, such as regularly playing a sport, carrying heavy loads at work, or going for a walk with friends. These are the findings of a new study led by Inserm researcher Jean-Philippe Empana (U970 PARCC, Inserm/Université de Paris) in collaboration with Australian researchers.

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Un « Google Maps » du système immunitaire pour prédire la réponse aux traitements contre le cancer

Une équipe conjointe Inserm et Institut Curie a développé une carte interactive des réponses immunitaires potentielles en cas de cancer.

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Aging with HIV Linked to Increased Risk of Cognitive Impairment

Thanks to antiretroviral therapies, it is possible to grow old with HIV under control. However, this chronic infection may not leave cognitive function unscathed. That is why Alain Makinson (Translational Research on HIV and Infectious Diseases unit, Montpellier University Hospital, Université de Montpellier, Inserm, IRD) and his team were interested in exploring the development of neurocognitive impairment (NCI), such as diminished attention, memory and motor capacity, in patients living with HIV in the ANRS EP58 HAND 55-70 study.

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