Category Archives: Immunology, inflammation, infectiology and microbiology

A good outcome for the CHILD-INNOVAC project: successful test in humans of a nasal vaccine against pertussis

The CHILD-INNOVAC European research programme, coordinated by Inserm, has enabled the development of an innovative vaccine that can be administered intranasally, to combat pertussis, which has shown a resurgence in developed countries in recent years. The research consortium, headed by Camille Locht, Director of the Centre for Infection and Immunity of Lille (a joint Unit involving Inserm, CNRS, Institut Pasteur de Lille and University of Lille Nord de France), today published promising results from Phase I clinical trials of the vaccine in human subjects in the online journal PLOS ONE.

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A prime target for the development of anti-inflammatories

For the first time, scientists from the Institut Pasteur and Inserm have demonstrated the key role played by a particular molecule in intestinal infection.

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Chemotherapy: when our intestinal bacteria provide reinforcement

Research jointly conducted by investigators at Institut Gustave Roussy, Inserm, Institut Pasteur and INRA (French National Agronomic Research Institute) has led to a rather surprising discovery on the manner in which cancer chemotherapy treatments act more effectively with the help of the intestinal flora (also known as the intestinal microbiota).

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Comment détruire les stocks de VIH?

Éradiquer le VIH de l’organisme demeure inaccessible. En raison notamment de stocks de virus cachés dans des cellules du système immunitaire : les macrophages. L’équipe de Philippe Benaroch vient de montrer qu’il était possible, grâce à des anticorps, de bloquer la libération de ces ”troupes ennemies” des compartiments internes où elles sont regroupées. Cette découverte, publiée à la une de la revue Journal of Experimental Medicine, ouvre un nouveau front dans la bataille contre le virus du sida.

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Identification of a new mechanism in the most commonly used immunotherapy for lymphoma

In a lymphoma model, the scientists have been able to carry out real time in vivo imaging of the cellular events activated by the treatment and resulting in the destruction of tumor cells.

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Une mutation d’un gène en cause dans une maladie infectieuse fongique, la dermatophytose profonde

Des chercheurs du laboratoire de Génétique Humaine des Maladies Infectieuses (Université Paris Descartes, Inserm), sous la direction du Dr Anne Puel et du Pr Jean-Laurent Casanova, en étroite collaboration avec des équipes françaises et étrangères*, viennent de démontrer l’implication du gène CARD9 dans la dermatophytose profonde.

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Fine-tuning the approach to malaria and toxoplasmosis research

A study carried out by teams from the Institut Pasteur, the Institut Cochin (Inserm, CNRS, Paris Descartes University), and the Wellcome Trust Centre for Molecular Parasitology at the University of Glasgow, may very well redefine current approaches to malaria and toxoplasmosis research in terms of treatment development.

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Circumcision effectively reduces the risk of HIV infection “in real life”

The ANRS-12126 “Bophelo Pele” Project implemented in the township of Orange Farm in South Africa has confirmed the effectiveness of a large-scale program of voluntary medical male circumcision in prevention of heterosexually acquired HIV infection. The follow-up of over 3300 men shows a 57% to 61% reduction in the rate of new HIV infections in circumcised men compared with uncircumcised men.

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Neutrophils: the Unsung Heroes of Immunotherapy Cancer Treatment

Scientists at the Institut Pasteur and Inserm have identified the group of cells within the immune system that make immunotherapy treatment (therapeutic antibodies) effective. Immunotherapy is frequently used to treat breast cancer. In animal models they showed that neutrophils, the most common white blood cells in the body, are not only necessary but suffice on their own to eliminate tumor cells.

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The way the virus continually changes complicates the development of a vaccine against HIV

VIH

A team from INSERM Mixed Research Unit 966 “Morphogenesis and Antigenicity of HI and Hepatitis Viruses” headed by Martine Braibant and Francis Barin in Tours, has confirmed, with the support of the ANRS, that the AIDS virus has gradually adapted itself to the immune response of the human population during the course of the epidemic.

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