Category Archives: Circulation, metabolism, nutrition

Atopic dermatitis: how allergens get on our nerves

Atopic dermatitis, or eczema, primarily affects infants and children, and manifests itself in hypersensitivity to allergens in the environment. A skin disease characterized by flare-ups, it is often treated with topical anti-inflammatories. A new study shows that immune cells and sensory neurons interact in the skin to form units that can detect allergens and trigger inflammation. A discovery that provides an insight into how atopic dermatitis works, and points the way to new therapeutic possibilities.

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Elaboration et validation de l’iBox, le premier outil universel de prédiction du risque de perte de rein greffé basé sur l’intelligence artificielle.

Des équipes de deux centres majeurs de transplantation rénale de l’AP-HP (à l’hôpital Necker-Enfants malades et à l’hôpital Saint-Louis) et de l’Université de Paris, ont coordonné, au sein du « Centre d’expertise de la transplantation d’organe » de l’unité Inserm 970 dirigé par le Pr Alexandre Loupy, une étude internationale ayant permis d’élaborer et de valider iBox, le premier algorithme universel de prédiction du risque de perte de rein greffé.

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The natural lipids in buttermilk could contribute to reducing cardiovascular risk in vulnerable populations

Un consortium français vient de montrer que la consommation de certains lipides présents naturellement dans les produits laitiers (appelés « lipides polaires ») pourrait réduire le risque cardiovasculaire chez les femmes ménopausées et en surpoids.

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A New Atherosclerosis Marker on the Way

A team of researchers are proposing a new radioactive tracer to locate atheromatous plaques in arterial walls, which can cause cardiovascular events.

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Fertility and endometriosis: a research update from Inserm

Today, around 1 in 8 couples seek help because they are struggling to conceive. Infertility has therefore become a public health problem, and the scientific community is rallying in response.

Also posted in Cell biology, development and evolution, Press releases, Immunology, inflammation, infectiology and microbiology | Tagged | Comments closed

Artificial Intelligence Facilitates Chemical Toxicity Evaluation: the Case of Bisphenol S

A novel IT tool based on artificial intelligence methods has made it possible to identify the toxic effects of bisphenol S – a frequent substitute for bisphenol A in food containers.

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Hypertension: A New Drug Coming Soon?

Firibastat is the first in a new class of antihypertensive drugs targeting the renin-angiotensin system in the brain.

Also posted in Press releases, Neurosciences, cognitives sciences, neurology and psychiatry | Tagged | Comments closed

Syndrome Temple and Silver Russell understanding of epigenetic mechanisms regulating fetal growth

A team Sorbonne / AP-HP / Inserm, led by Professor Irene Netchine, physiology professor at Sorbonne University and pediatrician at the Hospital Armand Trousseau AP-HP, studied the molecular mechanisms of the clinical similarity between syndrome Temple and Russell Silver syndrome. Their study, published in Science Advances , highlights the importance of gene network concept “imprinted” in the diagnosis and treatment of patients with these rare syndromes.

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Mieux comprendre les mécanismes de progression des lésions rénales à l’origine de l’insuffisance rénale chronique

L’équipe du Dr Guillaume Canaud, praticien hospitalo-universitaire à l’hôpital Necker-Enfants malades – AP-HP et à l’Université Paris Descartes, et chercheur à l’Inserm (INEM l’Institut Necker Enfants Malades – Centre de médecine moléculaire), a étudié, en collaboration avec celle du Pr Bonventre du Brigham and Women’s hospital – Harvard Medical School (Boston, USA), les mécanismes impliqués dans la progression de la fibrose des reins qui entraîne à terme une insuffisance rénale chronique. Ces travaux, qui ont été publiés dans la revue Science Translational Medicine le 23 janvier 2019, participent à l’identification d’une cible thérapeutique potentielle.

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MON 810 and NK603 GM Maize: No Effects Detected on Rat Health or Metabolism

A diet based on MON 810 or NK603 transgenic maize does not affect the health or metabolism of rats, under the conditions of the GMO 90+1 project1. This unprecedented study performed by a research consortium led by Inra brought together a number of partners2, including Inserm. The research was performed as part of the Risk’OGM program funded by the French Ministry of Ecological and Inclusive Transition. For six months, rats were fed a diet containing either GM maize (MON 810 or NK603) or non-GM maize, in varying concentrations. The researchers, using high-throughput biology techniques, did not identify any significant biological markers related to the transgenic maize diet. Neither did anatomic pathology examination reveal any alteration of the liver, kidneys or reproductive system of the rats fed diets containing these GMOs. This research, published on December 10, 2018 in Toxicological Sciences, does not reveal any harmful effects related to the consumption of these two types of GM maize in the rat even after lengthy periods of exposure.

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