Category Archives: Circulation, metabolism, nutrition

Les métastases au fil du sang

Imagerie de billes fluorescentes sont filmées à très haute vitesse,

Les cellules tumorales circulantes utilisent les réseaux lymphatiques et sanguins pour se disséminer dans l’organisme et former des métastases à distance de la tumeur primaire. Jacky Goetz, chercheur Inserm, et son équipe ont contribué à montrer que les propriétés des flux de ces liquides biologiques influent énormément sur le risque d’apparition de ces métastases. Ils ont notamment observé que le ralentissement du flux sanguin au niveau de la ramification des artères permettait aux cellules cancéreuses de s’accrocher à la paroi vasculaire et de s’extraire des vaisseaux pour aller coloniser les tissus.

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Les risques de complication de l’obésité dépendraient avant tout de la composition du tissu adipeux

Se reposer uniquement sur la quantité de masse grasse semble constituer une approche trop réductrice pour prédire efficacement le risque de complications métaboliques et cardiovasculaires associées à l’obésité. L’équipe Inserm de Laurent Lagrost (Inserm UMR1231 “Lipides, nutrition, cancer”, Université de Bourgogne-Franche-Comté, Dijon) montre que, chez la souris, c’est la composition du tissu adipeux, et non sa quantité, qui est associée à l’espérance de vie.

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Type 1 diabetes : a research update from Inserm

From the discovery of insulin in 1921 to the first ever pancreas transplants in the late 1960s, the recent history of type 1 diabetes research has brought scientific and medical advances which have transformed patient prognosis and quality of life. Here at Inserm, eleven teams distributed among nine units contribute their own endeavors. Their work primarily involves the characterization of pancreatic cells and improving knowledge of the disease (risk factors, genetic susceptibility, pathophysiological mechanisms) and its complications. One of these teams, based in Lille, is exploring islet transplantation, a promising technique discussed in a new publication in Diabetes Care[1] and in an update in The Lancet[2]. Other very interesting avenues currently being explored include immunotherapy and the development of artificial pancreases.

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Atopic dermatitis: how allergens get on our nerves

Atopic dermatitis, or eczema, primarily affects infants and children, and manifests itself in hypersensitivity to allergens in the environment. A skin disease characterized by flare-ups, it is often treated with topical anti-inflammatories. A new study shows that immune cells and sensory neurons interact in the skin to form units that can detect allergens and trigger inflammation. A discovery that provides an insight into how atopic dermatitis works, and points the way to new therapeutic possibilities.

Also posted in Molecular and structural bases of living organisms, Press releases | Tagged | Comments closed

Elaboration et validation de l’iBox, le premier outil universel de prédiction du risque de perte de rein greffé basé sur l’intelligence artificielle.

Des équipes de deux centres majeurs de transplantation rénale de l’AP-HP (à l’hôpital Necker-Enfants malades et à l’hôpital Saint-Louis) et de l’Université de Paris, ont coordonné, au sein du « Centre d’expertise de la transplantation d’organe » de l’unité Inserm 970 dirigé par le Pr Alexandre Loupy, une étude internationale ayant permis d’élaborer et de valider iBox, le premier algorithme universel de prédiction du risque de perte de rein greffé.

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The natural lipids in buttermilk could contribute to reducing cardiovascular risk in vulnerable populations

Un consortium français vient de montrer que la consommation de certains lipides présents naturellement dans les produits laitiers (appelés « lipides polaires ») pourrait réduire le risque cardiovasculaire chez les femmes ménopausées et en surpoids.

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A New Atherosclerosis Marker on the Way

A team of researchers are proposing a new radioactive tracer to locate atheromatous plaques in arterial walls, which can cause cardiovascular events.

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Fertility and endometriosis: a research update from Inserm

Today, around 1 in 8 couples seek help because they are struggling to conceive. Infertility has therefore become a public health problem, and the scientific community is rallying in response.

Also posted in Cell biology, development and evolution, Press releases, Immunology, inflammation, infectiology and microbiology | Tagged | Comments closed

Artificial Intelligence Facilitates Chemical Toxicity Evaluation: the Case of Bisphenol S

A novel IT tool based on artificial intelligence methods has made it possible to identify the toxic effects of bisphenol S – a frequent substitute for bisphenol A in food containers.

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Hypertension: A New Drug Coming Soon?

Firibastat is the first in a new class of antihypertensive drugs targeting the renin-angiotensin system in the brain.

Also posted in Press releases, Neurosciences, cognitives sciences, neurology and psychiatry | Tagged | Comments closed
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