Category Archives: Circulation, metabolism, nutrition

Microbiote : la géographie intestinale influence les interactions entre les bactéries et leurs virus

Les bactéries du microbiote sont soumises à la prédation de leurs virus, les bactériophages, mais une partie d’entre elles peut trouver refuge dans le mucus qui recouvre les tissus de l’intestin, permettant de garder les populations de bactériophages et de bactéries en équilibre.Telles sont les conclusions d’une étude dirigée par Laurent Debarbieux, directeur de recherche et responsable du laboratoire Bactériophage, bactérie, hôte à l’Institut Pasteur avec Luisa De Sordi, maître de conférences Sorbonne Université au Centre de recherche Saint Antoine (Sorbonne Université / Inserm).

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For diabetic patients confined during the Covid 19-epidemic, the AP-HP, in partnership with Inserm and University of Paris, launches CoviDIAB, a national application for information, prevention and support online

The AP-HP, the Federation of Diabetological Hospital Service and the AP-HP Connected Health Responsibility Centre offer this week to diabetic patients confined at home during the Covid-19 outbreak, a national programme of information, prevention and support for their health.

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The origin of satiety: brain cells that change shape after a meal

You just finished a good meal and are feeling full? Researchers from the CNRS, Inrae, University of Burgundy, Université de Paris, Inserm, and University of Luxembourg1 have just revealed the mechanisms in our brains that lead to this state. They involve a series of reactions triggered by a rise in blood glucose levels.

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A Vaccine Against Chronic Inflammatory Diseases

In animals, a vaccine modifying the composition and function of the gut microbiota provides protection against the onset of chronic inflammatory bowel diseases and certain metabolic disorders, such as diabetes and obesity.

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Metastasis: When Cancer Cells Hitch a Ride Through the Bloodstream

Imagerie de billes fluorescentes sont filmées à très haute vitesse,

Circulating tumor cells use the blood and lymphatic networks to disseminate within the body, forming metastases distant from the primary tumor. Inserm researcher Jacky Goetz and his Tumor Biomechanics team at the Molecular ImmunoRheumatology laboratory (Inserm/Université de Strasbourg) have helped to show that the flow properties of these biological fluids have a huge influence on the risk of developing metastases.

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Les risques de complication de l’obésité dépendraient avant tout de la composition du tissu adipeux

Se reposer uniquement sur la quantité de masse grasse semble constituer une approche trop réductrice pour prédire efficacement le risque de complications métaboliques et cardiovasculaires associées à l’obésité. L’équipe Inserm de Laurent Lagrost (Inserm UMR1231 “Lipides, nutrition, cancer”, Université de Bourgogne-Franche-Comté, Dijon) montre que, chez la souris, c’est la composition du tissu adipeux, et non sa quantité, qui est associée à l’espérance de vie.

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Type 1 diabetes : a research update from Inserm

From the discovery of insulin in 1921 to the first ever pancreas transplants in the late 1960s, the recent history of type 1 diabetes research has brought scientific and medical advances which have transformed patient prognosis and quality of life. Here at Inserm, eleven teams distributed among nine units contribute their own endeavors. Their work primarily involves the characterization of pancreatic cells and improving knowledge of the disease (risk factors, genetic susceptibility, pathophysiological mechanisms) and its complications. One of these teams, based in Lille, is exploring islet transplantation, a promising technique discussed in a new publication in Diabetes Care[1] and in an update in The Lancet[2]. Other very interesting avenues currently being explored include immunotherapy and the development of artificial pancreases.

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Atopic dermatitis: how allergens get on our nerves

Atopic dermatitis, or eczema, primarily affects infants and children, and manifests itself in hypersensitivity to allergens in the environment. A skin disease characterized by flare-ups, it is often treated with topical anti-inflammatories. A new study shows that immune cells and sensory neurons interact in the skin to form units that can detect allergens and trigger inflammation. A discovery that provides an insight into how atopic dermatitis works, and points the way to new therapeutic possibilities.

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Elaboration et validation de l’iBox, le premier outil universel de prédiction du risque de perte de rein greffé basé sur l’intelligence artificielle.

Des équipes de deux centres majeurs de transplantation rénale de l’AP-HP (à l’hôpital Necker-Enfants malades et à l’hôpital Saint-Louis) et de l’Université de Paris, ont coordonné, au sein du « Centre d’expertise de la transplantation d’organe » de l’unité Inserm 970 dirigé par le Pr Alexandre Loupy, une étude internationale ayant permis d’élaborer et de valider iBox, le premier algorithme universel de prédiction du risque de perte de rein greffé.

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The natural lipids in buttermilk could contribute to reducing cardiovascular risk in vulnerable populations

Un consortium français vient de montrer que la consommation de certains lipides présents naturellement dans les produits laitiers (appelés « lipides polaires ») pourrait réduire le risque cardiovasculaire chez les femmes ménopausées et en surpoids.

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