Monthly Archives: July 2016

Omega-3 fatty acids and stress management: growing links

The relationship between omega-3 fatty acid intake and adaptation to stress or anxiety is becoming clearer. Back in 2011, a team of researchers from INRA and Inserm showed that reducing the intake of omega-3 fatty acids in mice increased their stress. This phenomenon may be linked to impairment of the brain’s ability to produce endogenous cannabinoids, the “endocannabinoids,” brain lipids that control synaptic memory. To better understand the endocannabinoid-dependent links between anxiety and synaptic plasticity, the research team continued its experiments by testing different models of behavioural stress on the rodents. These studies are the subject of an article published in the journal Cell Reports on 21 July.

Long term correction of hyperbilirubinemia in animal models of Crigler-Najjar syndrome after AAV vector-mediated liver gene transfer

Dr. Federico MINGOZZI, Team Leader of the Immunology and Liver Gene Transfer unit at Généthon, (Inserm U951/UPMC), France, has demonstrated the long-term efficacy of an optimized AAV-UGT1A1 vector for the correction of Crigler-Najjar syndrome (CN) in two different animal models of the disease. This work, published in July 20, 2016 in Molecular Therapy Methods and Clinical Development was supported by the AFM-Telethon.

Thursday 21 july 2016

Sorry, this entry is only available in French. Legeneraliste.fr et Pourquoidocteur.fr soulignent que l’essai clinique ANRS-Ipergay « a confirmé l’efficacité de la Prophylaxie pré-exposition (PrEP) « à la demande » comme moyen de prévention contre le VIH chez les hommes ayant des relations homosexuelles ». Les résultats de cet essai ont été présentés lors de la 21e conférence internationale sur […]

Wednesday 20 july 2016

Sorry, this entry is only available in French. L’AFP, Le Figaro, Le Parisien et Nostalgie indiquent que des chercheurs de l’Unité Inserm 919 ont développé un anticorps, le Glunomab, aux effets thérapeutiques potentiels contre la sclérose en plaques. Les chercheurs ont testé l’anticorps dans un modèle expérimental de sclérose en plaques chez la souris. L’anticorps, […]

An antibody-based drug for multiple sclerosis

Inserm Unit U919, directed by Prof. Denis Vivien (“Serine Proteases and Physiopathology of the Neurovascular Unit”) has developed an antibody with potential therapeutic effects against multiple sclerosis. The study, directed by Fabian Docagne and published in Brain, paves the way for a new strategy to control the disease.

Attacks and risks of post-traumatic stress

In a traumatic event, such as the attacks on Paris on 13 November 2015, and on Nice on 14 July 2016, the risk for victims and witnesses of developing post-traumatic stress disorder (PTSD) is high.

New findings from analysis of malignant tumour progression

Researchers from Paris Descartes University, CNRS, Inserm, University Paris-Est Créteil (UPEC) and the Paris Public Hospitals (AP-HP) have shown that analysis of epigenetic modifications could be used as a universal marker for monitoring tumour DNA circulating in the bloodstream of patients with colorectal cancer. This study is based on hypermethylation analysis of two genes (WIF1 and NPY) using a cutting-edge method: droplet-based digital PCR[1]. These results were published on 1 June 2016 in the journal Clinical Chemistry.

Tuesday 19 july 2016

Sorry, this entry is only available in French. Carole Damiani, docteur en psychologie clinique et spécialiste de l’aide aux victimes, chargée de mission à l’Inavem (fédération nationale d’aide aux victimes et de médiation), souligne, quatre jours après l’attentat de Nice, « quand le psychisme est atteint, il y a des conséquences très souvent physiques » […]

Malaria: a genetically attenuated parasite induces an effective, long-lasting immune response

With nearly 3.2 billion people currently at risk of contracting malaria, scientists from the Institut Pasteur, the CNRS and Inserm have experimentally developed a live, genetically attenuated vaccine for Plasmodium, the parasite responsible for the disease. By identifying and deleting one of the parasite’s genes, the scientists enabled it to induce an effective, long-lasting immune response in a mouse model. These findings were published in the Journal of Experimental Medicine on July 18, 2016

Monday 18 july 2016

Sorry, this entry is only available in French. La 21e conférence internationale sur le sida se déroule, à partir d’aujourd’hui et jusqu’à vendredi, en Afrique du Sud, à Durban, rapporte Le Figaro. Y participeront « l’élite des chercheurs scientifiques et médicaux et les décideurs du monde entier », explique le journal. Si de nombreux progrès ont été […]

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