Monthly Archives: January 2022

4 février 2022 : Journée mondiale contre le cancer

De nombreux travaux s’intéressent aux mécanismes d’apparition des tumeurs mais aussi à leur progression et aux causes des échappements thérapeutiques. Il s’agit de mieux comprendre le cancer pour permettre la découverte de nouveaux traitements qui soient adaptés à chacun et aux différentes pathologies.

Covid-19 : Une revue pour comprendre les facteurs génétiques et immunologiques responsables des pneumopathies

Coronavirus SARS-CoV-2

Depuis le début de la pandémie, des recherches ont été menées pour expliquer la grande hétérogénéité clinique du Covid-19 et identifier les causes des formes sévères. Les travaux des scientifiques de l’Inserm, d’Université de Paris et de l’AP-HP à l’Institut Imagine et à l’Université Rockefeller, coordonnés par Jean-Laurent Casanova et Laurent Abel, ont permis des avancées dans ce domaine.

Persistence of severe hepatic fibrosis despite substantial weight loss with bariatric surgery

A study on the effects of bariatric surgery on the severity of liver damage in patients with NASH (Non-Alcoholic Steatohepatitis or Metabolic Steatohepatitis) and severe fibrosis (bridge fibrosis or compensated cirrhosis) shows that in 50% of patients who underwent bariatric surgery, despite significant weight loss (20% to 30% of initial BMI) and improvement in metabolic risk factors (mainly type 2 diabetes), severe fibrosis persists in the medium term (5 years after surgery).

Improvement in the Health of Two Infants with Severe Disharmonious Overgrowth Syndromes

A new study reports clinical, biological, and imaging improvements in two infants with severe forms of disharmonious overgrowth syndromes treated with alpelisib. These are the first data obtained on the use of this molecule in severe neonatal forms of the disease.

Sickle cell disease and transfusion-dependent beta thalassemia: promising results of gene therapy treatment

Globules rouges en forme de faucille (drépanocytose)

Teams of researchers conducted a clinical gene therapy study consisting of transplanting in the patient’s own genetically modified hematopoietic stem cells. This phase I/II clinical trial was carried out in patients with sickle cell disease or transfusion-dependent beta thalassemia, common genetic diseases that affect red blood cells.

Study of gene therapy treatment in Wiskott-Aldrich syndrome

Researchers have carried out work on treatment by gene therapy consisting of transplanting the patient’s own genetically modified hematopoietic stem cells as part of a phase I/II clinical trial in 8 patients with Wiskott-Aldrich syndrome (WAS).

New Brain Abnormalities Associated with Child Abuse

In collaboration with a Canadian team, scientists from Inserm and Université de Tours, at Unit 1253 Imaging & Brain1, have shown in post-mortem brain samples that victims of child abuse present specific brain characteristics. This research suggests that abuse could cause lasting changes to the developmental trajectories of certain brain regions with potential effects on psychological health.

Cyclists and Pedestrians Inhale More Road Traffic Particles Than Motorized Transport Users

A team of scientists led by Inserm Research Director Basile Chaix at the Pierre Louis Institute of Epidemiology and Public Health (Inserm/Sorbonne Université) studied the impact of these parameters on exposure to black carbon, an air pollutant produced by road traffic.

Un récepteur synaptique impliqué dans l’émergence de croyances aberrantes

Pourquoi sommes-nous parfois enclins à croire à l’improbable envers et contre tout ? Une étude menée par une équipe de neuroscientifiques et de médecins psychiatres pointe vers un récepteur synaptique spécifique. Son blocage induit des décisions prématurées et aberrantes, ainsi que des symptômes ressemblant à ceux rapportés dans les stades précoces de psychose.

Des mesures qui payent pour lutter contre la pollution atmosphérique

Reducing fine particle mortality in a conurbation by two-thirds could be achieved at a cost that is much lower than the value of the societal and economic benefits obtained, according to a study by a multidisciplinary team from CNRS, INSERM, INRAE, Grenoble Alpes University (UGA) and Atmo Auvergne-Rhône-Alpes. The study identifies specific public policies that could achieve health objectives set by local decision makers, as well as their expected co-benefits.

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