Several months after infection with SARS-CoV-2, some patients still have symptoms: a phenomenon commonly referred to as "long COVID". Teams from Inserm and Université Paris Cité, in collaboration with the University of Minho in Braga (Portugal), have shown that this could be explained biologically by abnormalities of the immune system associated with the persistence of the virus in the mucous membranes.
A large part of the population has developed immunity against SARS-CoV-2 following infection, vaccination – or both. In addition, some infected patients enjoy "hybrid" immunity when they are vaccinated following their infectious episode.
In crowded places, such as airports and train stations, social distancing is difficult to maintain and the risk of infectious disease transmission is increased. In order to reduce this risk, it is essential that we improve our understanding of the dynamics of disease transmission within such places and the effective mitigation measures that can be implemented at low cost.
In a new study, scientists from Inserm and Université de Montpellier at the Montpellier Cancer Research Institute, in collaboration with Montpellier University Hospital, have highlighted the possible role of the dysregulation of a part of the innate immune defense. They suggest that the production of "extracellular neutrophil traps", a first-line defense mechanism against pathogens, could play a role in the persistence of symptoms six months later in patients having...
How can we increase the efficacy of vaccines used to protect against viral respiratory diseases such as influenza and COVID-19? Scientists from Inserm, CNRS and Aix-Marseille Université at the Center of Immunology Marseille-Luminy are opening up new prospects in the field, with the triggering of memory B cells directly in the lungs looking to be a promising avenue. At present, the vaccines are administered intramuscularly and do not trigger...
Dans une nouvelle étude, des scientifiques ont identifié, à partir des données de près de 26 000 volontaires de la cohorte Constances, quels symptômes persistants sont le plus fréquemment rapportés par les personnes ayant été infectées par le SARS-CoV-2 comparé au reste de la population. Il s’agit principalement de la perte de goût ou d’odorat, de gêne respiratoire ou de fatigue.
L’ensemble des membres fondateurs s’interroge sur la tenue d’un tel évènement au sein d’un Institut hospitalo-universitaire. L’intitulé et la nature des participants et des associations partenaires ne laissent aucun doute sur les objectifs. Par conséquent, les membres fondateurs demandent la délocalisation de cette conférence.
A new modeling study by researchers from Inserm and Sorbonne Université at the Pierre Louis Institute of Epidemiology and Public Health shows that a "reactive" vaccination strategy targeting homes, schools and workplaces where cases are detected could have beneficial effects, reducing the number of COVID-19 cases in certain epidemic situations.
Researchers describe how basophils respond to SARS-CoV-2 infection. They show that exposure to the virus activates them, leading to the production of certain cytokines and helping to reduce inflammation and promote the secretion of antibodies.