A new modeling study by researchers from Inserm and Sorbonne Université at the Pierre Louis Institute of Epidemiology and Public Health shows that a "reactive" vaccination strategy targeting homes, schools and workplaces where cases are detected could have beneficial effects, reducing the number of COVID-19 cases in certain epidemic situations.
Scientists have discovered a mechanism that enables cells infected with Listeria monocytogenes to escape immune responses. This mechanism provides infected cells circulating in the blood with a higher probability of adhering to and infecting cells of cerebral vessels, thereby enabling bacteria to cross the blood-brain barrier and infect the brain.
In a new study, researchers from Inserm and Université de Bordeaux at the Bordeaux Population Health Research Center, in collaboration with the Research Institute for Sustainable Development (IRD) and the NGO ALIMA (The Alliance for International Medical Action), have developed and tested a new strategy to simplify and optimize the treatment of malnutrition in order to help a larger number of children.
Researchers report that the MICA gene is a new histocompatibility gene, in that it helps to better explain and predict the success or failure of a kidney transplant. Their findings have been published in Nature Medicine.
Researchers from Inserm, Université de Rennes 1 and the EHESP School of Public Health at Irset wished to identify the impact on cognitive performance of three pollutants linked to road traffic (fine particles of less than 2.5 microns in diameter, nitrogen dioxide and black carbon). They compared the results of cognitive tests performed by a large sample of people according to their level of exposure to these different pollutants....
The infant mortality rate (IMR) is a key indicator of population health. Researchers analyzed civil registry data from the French National Institute of Statistics and Economic Studies (INSEE) from 2001 to 2019. They identified a significant increase in the IMR since 2012, thereby setting France apart from other high-income countries.
Researchers from the Institut Pasteur and Inserm discovered that innate effector cells – group 3 innate lymphoid cells – act not only during the early stages of infection but can also be trained to develop an innate form of immunological memory that can protect the host during reinfection.
Researchers describe how basophils respond to SARS-CoV-2 infection. They show that exposure to the virus activates them, leading to the production of certain cytokines and helping to reduce inflammation and promote the secretion of antibodies.
Annually over 50,000 bone marrow transplantations occur worldwide as a therapy for multiple cancerous and non-cancerous diseases. Yet, how this procedure gives rise to bone marrow-derived cells that engraft the brain, despite being absent in the normal brain, remains unknown. Scientists discovered how the host’s microglia, the brain’s innate immune cells, are replaced by bone marrow-derived macrophages. The key discovery was that transplantation chemotherapy eliminated the microglia’s regenerative capacity,...
A Swiss-French team that includes UNIGE scientists has discovered how to trigger apoptosis in leukaemia cells by disrupting their energy maintenance mechanism.
