Researchers from the Institut Pasteur, Inserm, CNRS and Paris Descartes – Sorbonne Paris Cité University recently published a large-scale study in Nature Genetics based on almost 7,000 strains of Listeria monocytogenes — the bacterium responsible for human listeriosis, a severe foodborne infection. Through the integrative analysis of epidemiological, clinical and microbiological data, the researchers have revealed the highly diverse pathogenicity of isolates belonging to this bacterial species. Comparative genomics led...
The European Commission has granted over 22 million Euros to the European HIV Vaccine Alliance (EHVA) to develop a multidisciplinary platform to evaluate novel preventive and therapeutic vaccines.
Using innovative technology, scientists from the Institut Pasteur and Inserm have filmed in vivo the process by which an AIDS vaccine candidate, developed by the French Vaccine Research Institute and the ANRS, triggers the immune response. This previously unseen footage clearly shows how the vaccine recruits the immune cells needed to destroy infected cells. These results, published in the journal Nature Medicine on December 21, 2015, shed new light...
Despite excessive alcohol consumption, some individuals remain in good health while others develop liver disease. This inequality regarding the toxicity of alcohol for the liver depends on the intestinal microbiota. This has just been demonstrated by scientists and physicians from Paris-Sud University, Inserm, AP-HP (Antoine-Béclère Hospital), INRA (French National Institute for Agricultural Research), AgroParitech and Aix-Marseille University. These results are published online in the journal Gut.
Éric Vivier’s team at Marseille-Luminy Immunology Center (CIML), a CNRS, Inserm and Aix-Marseille University research centre, in collaboration with Gabrielle Belz’s team at Walter and Elisa Hall Institute (WEHI), Melbourne, sheds new light on the dynamics of the immune networks that protect our intestine. During episodes of bacterial diarrhoea, innate lymphoid cells (ILCs) “share the work” with memory T lymphocytes, but can also compensate for them in the event...
Announced at the end of 2014 during the final phase of research and development, the rapid diagnostic test for Ebola virus disease developed by the French Atomic Energy Commission (CEA), with support from the Inserm Jean Mérieux P4 high-level biological containment laboratory (Lyon), has been assessed in the field, including in Guinea, over a period of several months.
The efforts of the international community for the past ten years in the fight against malaria have reduced the number of disease-related deaths. The emerging resistance to standard therapies threatening South-East Asia, and new research carried out by the team led by Françoise Benoit-Vical, are not reassuring factors.
Researchers have recently shown how microbiota protects against the development of type 1 diabetes.
A large-scale collaborative study revealed the acquisition of multi-resistant enterobacteria (MRE) in one in two travellers returning from a stay in a country situated in a tropical region.
Scientists at the Institut Pasteur and Inserm have successfully increased the infiltration of immune cells into tumors, thus inducing the immune system to block tumor growth.