Researchers demonstrated the efficacy of gene therapy treatment for Wiskott-Aldrich Syndrome (WAS). Six children that were treated and followed for at least 9 months had their immune system restored and clinical condition improved.
By analysing the genome of a little girl who contracted a severe form of influenza at the age of two and a half years, researchers have discovered that she has a genetic mutation, unknown until now, that causes a subtle dysfunction in her immune system.
Une collaboration internationale conduite par le Professeur Thomas Baumert met en évidence qu’un anticorps monoclonal spécifiquement dirigé contre la claudine-1, permet de prévenir et de traiter une infection chronique par ce virus dans un modèle animal.
Basic research on blood pressure has led researchers from Inserm (Inserm Unit 1138, “Cordeliers Research Centre”) to obtain unexpected results: drugs used to treat hypertension (high blood pressure) reduce side effects from corticosteroid-based creams used to treat certain skin diseases.
Preliminary data from the JIKI clinical trial, which is testing the efficacy of favipiravir in reducing mortality associated with Ebola, provide two important pieces of information: • absence of efficacy in individuals who arrive at treatment centres with a very high level of viral replication and who already have serious visceral involvement, • and encouraging signs of efficacy in individuals arriving at treatment centres with a high or moderate level of viral...
Scientists from the CNRS, INSERM and Université de Limoges have demonstrated that the production of type E immunoglobulins (IgE) by B lymphocytes induces a loss in their mobility and the initiation of cell death mechanisms.
A study has focused on the evolutionary history of the mycobacterium that causes tuberculosis, and more specifically on the Beijing lineage associated with the spread of multidrug resistant forms of the disease in Eurasia.
A clinical trial project, coordinated by Inserm, involving the testing of a preventive vaccine against Ebola has been selected by the European Commission.
The complete genomes of 16 anopheline mosquito species from the five continents have just been sequenced. Ten years of research have enabled an international consortium, coordinated by the University of Michigan and University of Notre Dame (United States) and including researchers from the French Institute for Development Research (IRD) and Inserm, to publish in the 27 November 2014 issue of the journal Science the DNA sequence for these mosquitoes,...
The Ebola epidemic is continuing to spread, particularly in West Africa. According to the latest report by the World Health Organisation (WHO) dated 17 October, 9,216 cases of Ebola have been recorded and 4,555 people have died of the virus. With the current situation of the Ebola epidemic, it quickly became necessary for French research to be mobilised rapidly.
Erosive oral lichen planus (OLP) is an auto-immune disease affecting skin and mucous membranes which results in an abnormal immune response against mucocutaneous cells.
