How is it that certain patients infected by HIV have immune cells that are capable of controlling the infection? Victor Appay, INSERM Research Director (Mixed INSERM Research Unit 945 “ Immunity and Infection” / Université Pierre and Marie Curie / Hôpital Pitié-Salpêtrière (AP-HP)) and his colleagues have succeeded in identifying the molecular characteristics of certain T lymphocytes that have the specific property of being able to detect and...
Antimicrobial resistance represents is a growing problem in public health due the increasing rarity of antibiotics capable of combating resistant bacteria. The COMBACTE project, that has just obtained 195 million euros worth of finance from the Innovative Medicines Initiative (IMI), aims to work to develop new antibiotics and introduce a successful clinical trials platform combining private and public research.
The HOMAGE (Heart OMics in AGEing) project, coordinated by the French National Institute of Health and Medical Research (INSERM), has been awarded a grant by the European Commission for a 6 year period. The project aims to identify and validate specific biomarkers of heart failure in order to prevent the development of the disease affecting elderly population. 17 research groups from 10 countries will collaborate to investigate new ways...
Weak concentrations of bisphenol A are sufficient to produce a negative reaction on the human testicle. This has just been shown experimentally for the first time by René Habert and his colleagues (UMR Cellules souches et Radiations [UMR Stem Cells and Radiation], Inserm U 967 - CEA - Paris Diderot University) in an article that appeared in the journal entitled Plos One.
Julien Diana and Yannick Simoni of the "Immune Mechanisms in Type 1 Diabetes” (Inserm/Université Paris Descartes), directed by Agnès Lehuen, have just published the results of their work on type 1 diabetes in the Nature Medicine journal. This is a disease characterised by the self-destruction of the p pancreatic cells that produce insulin.
L’équipe de Behazine Combadière, Directrice de recherche Inserm au sein de l’Unité mixte de recherche 945 « Immunité et infection » (Inserm-Université Pierre et Marie Curie) à l’Hôpital Pitié-Salpêtrière, Paris, vient de montrer que la réponse immunitaire après vaccination par la voie intradermique déclenche la prolifération de cellules de l’immunité et la maturation de celles-ci dans un site jusque-là considéré comme un site de stockage des cellules « mémoires...
The researcher Capucine Picard, working with the team from Inserm unit 980 "Human genetics and infections diseases" has succeeded in identifying the part played by the HOIL1 gene in cases of paradoxal association of an immune deficiency with a chronic autoinflammatory deficiency and a muscular deficiency in 3 children from 2 different families.
A study carried out by Ali Amara's team at the combined Inserm/CNRS- Université Paris Diderot "Molecular pathology and virology" unit in the Saint-Louis hospital in Paris, working jointly with the team from the Pasteur Institute in Paris and the team from the Salk Institute in San Diego, has identified two families of receptors that play an important part in the penetration of the Dengue virus into cells.
Two new tests capable of rapidly diagnosing resistance to wide-spectrum antibiotics have just been developed by Inserm Unit 914 "Emerging resistances to antibiotics"
Only 10% of individuals infected by Mycobacterium tuberculosis, which causes tuberculosis, go on to develop the disease.
