Researcher Contact
Roland Liblau Director of the Toulouse Purpan Pathophysiology Center (CPTP) Inserm UMR1043 – CNRS UMR5282 – University of Toulouse III +33 5 62 74 45 15 roland.liblau@inserm.fr
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In order to study the potential autoimmune aetiology, Inserm researchers at Unit 1043, the “Toulouse Purpan Pathophysiology Center” (Inserm/University of Toulouse/CNRS), have developed a mouse model that mimics narcolepsy. They thus generated mice expressing an autoantigen, haemagglutinin, specifically in the orexinergic neurons (Orex-HA mice). The mice were injected with effector T cells specific for this autoantigen.
CD4 T cells infiltrated the hypothalamus and triggered local inflammation, but did not induce destruction of the orexinergic neurons, in contrast to cytotoxic CD8 T cells. This neuronal loss led to cataplexy and sleep disorders in these mice, mimicking human narcolepsy.
Immunology, inflammation, infectiology and microbiology Voir tout
Roland Liblau Director of the Toulouse Purpan Pathophysiology Center (CPTP) Inserm UMR1043 – CNRS UMR5282 – University of Toulouse III +33 5 62 74 45 15 roland.liblau@inserm.fr
CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice. Raphaël Bernard-Valnet, Lidia Yshii, Clémence Quériault, Xuan-Hung Nguyen, Sébastien Arthaud, Magda Rodrigues, Astrid Canivet, Anne-Laure Morel, Arthur Matthys, Jan Bauer, Béatrice Pignolet, Yves Dauvilliers, Christelle Peyron, Roland Liblau. Doi: 10.1073/pnas.1603325113 PNAS, septembre 2016