Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death
Florent Sauve1#, Sreekala Nampoothiri1#, Sophie A. Clarke2#, Daniela Fernandois1#, Caio Fernando Ferreira Coêlho1#, Julie Dewisme1,3, Edouard G. Mills2, Gaetan Ternier1, Ludovica Cotellessa1, Cristina Iglesias-Garcia5, Helge Mueller-Fielitz6, Thibaud Lebouvier1,7, Romain Perbet1,3, Vincent Florent1, Marc Baroncini1, Ariane Sharif1, June Ereño-Orbea8, Maria Mercado-Gómez8, Asis Palazon8, Virginie Mattot1, Florence Pasquier1,7, Sophie Catteau-Jonard1,9, Maria Martinez-Chantar8, Erik Hrabovszky10, Mercé Jourdain11, Dominique Deplanque1,12,13, Annamaria Morelli14, Giulia Guarnieri14, Laurent Storme15, Cyril Robil16, François Trottein16, Ruben Nogueiras5, Markus Schwaninger6, Pascal Pigny17‡, Julien Poissy13,18‡, Konstantina Chachlaki1‡, Claude-Alain Maurage1,3,13‡, Paolo Giacobini1‡, Waljit Dhillo2,19‡, S. Rasika1‡, Vincent Prevot1‡
1 Univ. Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, UMR-S 1172, FHU 1000 days for health, EGID, Lille, France
2 Section of Endocrinology and Investigative Medicine, Imperial College London, London, United Kingdom.
3 CHU Lille, Department of Pathology, Centre Biologie Pathologie, France
5 CIMUS, Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain
6 Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany
7 CHU Lille, Department of Neurology, Memory Centre, Reference Centre for Early-Onset Alzheimer Disease and Related Disorders, Lille, France
8 CIC bioGUNE, Basque Research and Technology Alliance (BRTACentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain. 48160 Derio, Bizkaia
Technology Park, Building 801A, Bizkaia, Spain
9 CHU Lille, Department of Gynecology and Obstetrics, Jeanne de Flandres Hospital, F-59000 Lille, France
10 Laboratory of Reproductive Neurobiology, Institute of Experimental Medicine, Budapest, Hungary
11 Univ. Lille, Inserm, CHU Lille, Service de Médecine Intensive Réanimation, U1190, EGID, F-59000 Lille, France.
12 Univ. Lille, Inserm, CHU Lille, centre d’investigation clinique (CIC) 1403, F-59000 Lille, France.
13 LICORNE study group, CHU Lille, Lille, France
14 Department of Experimental and Clinical Medicine, University of Florence, Italy
15 CHU Lille, Department of Neonatology, Hôpital Jeanne de Flandre, FHU 1000 days for health, F-59000, France
16 Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 – UMR 9017 – CIIL – Center for Infection and Immunity of Lille, F-59000 Lille, France
17 CHU Lille, Service de Biochimie et Hormonologie, Centre de Biologie Pathologie, Lille, France
18 Univ. Lille, Inserm U1285, CHU Lille, Pôle de réanimation, CNRS, UMR 8576 – UGSF – Unité de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille, France
19 Department of Endocrinology, Imperial College Healthcare NHS Trust, London, United Kingdom
# These authors contributed equally to this work.
‡ These authors contributed equally to this work
eBioMedicine, 13 septembre 2023