Acute-on-Chronic Liver Failure is a Distinct Syndrome that Develops in Patients With Acute Decompensation of Cirrhosis
Richard Moreau,* Rajiv Jalan,‡ Pere Gines,§ Marco Pavesi,║Paolo Angeli,¶ juan cordoba,# François Durand,* Thierry Gustot,** Faouzi Saliba,‡‡ Marco Domenicali,§§ Alexander Gerbes,║║Julia Wendon,¶¶ Carlo Alessandria,## Wim Laleman,*** Stefan Zeuzem,‡‡‡ Jonel Trebicka, §§§ Mauro Bernardi,§§ Vicente Arroyo,§ for the canonic study investigators of the easl-clif consortium
* Service d’Hépatologie, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Clichy; Inserm U773, Centre de Recherche Biomédicale Bichat-Beaujon CRB3, Clichy and Paris; and Université Paris Diderot-Paris 7, Paris, France;
‡ Institute of Liver and Digestive Health, Liver Failure Group, Royal Free Campus, London, United Kingdom;
§ Liver Unit, Hospital Clinic, University of Barcelona, IDIBAPS, Centro de Investigacion Biomedica en Red Enfermedades Hepaticas y Digestivas (CIBERehd), Barcelona, Spain;
║Data Management Centre, CLIF Consortium, Hospital Clinic, Centro de Investigacion Biomedica en Red Enfermedades Hepaticas y Digestivas (CIBERehd), Barcelona, Spain;
¶ Department of Medicine, Unit of Hepatic Emergencies and Liver Transplantation, University of Padova, Padova, Italy;
# Servicio de Hepatologia, Hospital Vall d’Hebron, Universitat Autonoma de Barcelona, Centro de Investigacion Biomedica en Red Enfermedades Hepaticas y Digestivas (CIBERehd), Barcelona, Spain;
** Department of Gastroenterology and Hepato-Pancreatology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium;
‡‡ Centre Hépato-Biliaire, Hôpital Paul Brousse, Assistance Publique- Hôpitaux de Paris, Villejuif, France; §§Semeiotica Medica, Policlinico S. Orsola-Malpighi, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy;
║║Liver Center Munich, Department of Medicine 2, Klinikum der LMU Munchen-Grosshadern, Munich, Germany;
¶¶Institute of Liver Studies and the Cellular Biology of Inflammation, King's College Hospital, London, United Kingdom;
## Division of Gastroenterology and Hepatology, San Giovanni Battista Hospital,University of Turin, Turin, Italy;
***Department of Liver and Biliopancreatic Diseases, University Hospital Gasthuisberg, KU Leuven, Leuven, Belgium;
‡‡‡ Department of Medicine I, JW Goethe University Hospital, Frankfurt, Germany; §§§Department of Internal Medicine I, University Hospital of Bonn, Bonn, Germany
Gatroenterology, avril 2013