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Migraine to the Tip of the Genes

24 Jun 2013 - 12h31 | By INSERM PRESS OFFICE | Neurosciences, cognitives sciences, neurology and psychiatry

An international consortium has just revealed five new genetic regions associated with migraine in a study published on 23 June 2013 in the journal Nature Genetics, bringing the total number identified in recent years to 12. Researchers from Inserm Unit 708 “Neuroepidemiology” in Bordeaux participated in the vast research by comparing nearly 118,000 items of data from patients suffering or not suffering from migraine, produced from 29 different genomic studies.

Migraine is a type of repetitive headache characterised by very intense pain and other symptoms such as nausea, sensitivity to light and noise. It affects almost one adult in five. A study of the origins remains difficult due to the episodic nature of the complaint but, very recently, several genetic markers have been associated with migraine.

In this new study, researchers listed 12 genetic regions associated with migraine. Seven of them had already been reported and five new ones were identified.

The study shows that some of them can be found near the genes controlling the brain circuits and the genes responsible for maintaining brain tissue in good health.

“The results obtained from this very large database will make it possible to determine the biological mechanisms for the origin of migraines” explains Tobias Kurth, Inserm Research Director at Inserm Unit 708 “Neuroepidemiology”. We believe that most of these genes are interconnected and could deregulate brain tissue thus producing the symptoms of migraine,” he adds.

Researchers also identified 134 additional genetic regions that are potentially associated with an individual’s susceptibility to developing migraine.

Inserm press room Migraine to the Tip of the Genes Link :
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Tobias Kurth Research director Inserm Unité 708 Neuroépidémiologie (Inserm/Université Bordeaux Segalen)


Genome-wide meta-analysis identifies new susceptibility loci for migraine

Nature Genetics, 23 juin 2013

Verneri Anttila1,2,3,4,70, Bendik S. Winsvold1,5,70, Padhraig Gormley1, Tobias Kurth6,7,8, Francesco Bettella9, George McMahon10, Mikko Kallela11, Rainer Malik12, Boukje de Vries13, Gisela Terwindt14, Sarah E. Medland15, Unda Todt16, Wendy L. McArdle10, Lydia Quaye17, Markku Koiranen18, M. Arfan Ikram19,20,21, Terho Lehtimäki22, Anine H. Stam14, Lannie Ligthart23,24, Juho Wedenoja25, Ian Dunham26, Benjamin M. Neale3,4, Priit Palta1,2, Eija Hamalainen1,2, Markus Schürks27, Lynda M Rose8, Julie E.  Buring8, Paul M. Ridker8,28, Stacy Steinberg9, Hreinn Stefansson9, Finnbogi Jakobssonxxx, Debbie A.  Lawlor10, David M. Evans10, Susan M. Ring10, Markus Färkkilä11, Ville Artto11, Mari A Kaunisto2,29,  Tobias Freilinger12,30, Jean Schoenen31, Rune R. Frants13, Nadine Pelzer14, Claudia M. Weller13, Ronald  Zielman14, Andrew C. Heath32, Pamela A.F. Madden32, Grant W. Montgomery15, Nicholas G. Martin15, Guntram Borck16, Hartmut Göbel33, Axel Heinze33, Katja Heinze-Kuhn33, Frances M.K. Williams17, Anna-Liisa Hartikainen34, Anneli Pouta18,34,35, Joyce van den Ende19, Andre G. Uitterlinden36, Albert  Hofman37, Najaf Amin19, Jouke-Jan Hottenga23, Jacqueline M. Vink23, Kauko Heikkilä25, Michael Alexander38,39, Bertram Muller-Myhsok40,69, Stefan Schreiber41,42, Thomas Meitinger43,44, Heinz Erich  Wichmann45,46,47, Arpo Aromaa48, Johan G. Eriksson29,48,49,50,51, Bryan Traynor52, Daniah Trabzuni53,54, North American Brain Expression Consortium55, UK Brain Expression Consortium55, Elizabeth Rossin3,4,56, Kasper Lage3,4,57,58,59, Suzanne B.R. Jacobs4, J. Raphael Gibbs52,53, Ewan Birney26, Jaakko Kaprio2,60,25, Brenda W. Penninx63,24,62,61, Dorret I. Boomsma23, Cornelia van Duijn19, Olli Raitakari64,65, Marjo-Riitta Jarvelin66,18,67,35, John-Anker Zwart5, Lynn Cherkas17, David P. Strachan68, Christian Kubisch16, Michel D. Ferrari14, Arn M.J.M. van den Maagdenberg13,14, Martin Dichgans12,69, Maija Wessman2,29, George Davey Smith10, Kari Stefansson9,xxx2, Mark J. Daly3,4, Dale R. Nyholt15, Daniel Chasman8,28, Aarno Palotie1,2,4, for the International Headache Genetics Consortium55.

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