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Researchers from Inserm, CNRS and Université Grenoble Alpes working at the Institute for Advanced Biosciences (Joint Research Unit 1209) have analyzed the consequences of environmental exposure in utero using data collected from a cohort of 668 women. Exposure to atmospheric pollution is associated with epigenetic modifications in the placenta, presenting a risk to the fetus. These findings were published in Environment International on June 21, 2018.
Exposure to air pollution during pregnancy presents a risk to the health of the fetus and child. According to a number of studies, exposure to air pollution is linked to harmful effects, such as preeclampsia (hypertension associated with the presence of protein in the urine) in the pregnant woman, as well as reduced birth weight and possibly also lung function deterioration and neurodevelopmental disorders in the child. The mechanisms that explain the effect of air pollutants on the development of the fetus and child could involve impairment of the placenta.
The researchers conducted a study based on 668 mothers and their children in the EDEN cohort. The pregnant women were recruited between 2003 and 2006 in the university hospitals of Nancy and Poitiers. The scientists observed that the mothers most exposed to nitrogen dioxide (gas produced by automobile, industrial and thermal combustion processes) during their pregnancies presented an epigenetic modification on the ADORA2B gene. “Defects in the expression of this gene have in other studies been associated with preeclampsia, a commonly-occurring condition in pregnancy which can be serious if it is not managed,” explains Inserm researcher, Johanna Lepeuler. The average exposure levels in the population studied were below the annual limit set by the European Union air quality directive (40 mg/m3 for nitrogen dioxide).
It is the first study on air pollutants to focus on the issue based on an analysis of large-scale epigenetic data (concerning more than 400,000 epigenetic locations). Previous studies focused on specific genes.
Johanna LEPEULE Inserm Researcher Institute for Advanced Biosciences (Inserm U 1209 / CNRS UMR 5309 /Université Grenoble Alpes) Environmental Epidemiology applied to Reproduction and Respiratory Health team Tel.: +33 (0)4 76 54 94 63 johanna.lepeule@univ-grenoble-alpes.fr
Pregnancy exposure to atmospheric pollution and meteorological conditions and placental DNA methylation Emilie Abrahama, Sophie Rousseauxa, Lydiane Agiera, Lise Giorgis-Allemanda, Jörg Tostb, Julien Galineauc, Agnès Hulind, Valérie Sirouxa, Daniel Vaimane, Marie-Aline Charlesf, Barbara Heudef, Anne Forhanf, Joel Schwartzg, Florent Chuffarta, Ekaterina Flina, Saadi Khochbina, Rémy Slamaa, Johanna Lepeulea on behalf of the EDEN mother-child cohort study group. a Univ. Grenoble Alpes, Inserm, CNRS, IAB, 38000 Grenoble, France; b Laboratory for Epigenetics and Environment, Centre National de Recherche en Génomique Humaine, CEA – Institut de Biologie François Jacob, Evry, France; c Air Lorraine, Nancy, France; d ATMO Poitou-Charentes, La Rochelle, France; e Genomics, Epigenetics and Physiopathology of Reproduction, Institut Cochin, U1016 Inserm –UMR 8104 CNRS – Paris-Descartes University, Paris; f Inserm U1153, Early Origins of Child Health and Development team, Research Center for Epidemiology and Biostatistics Sorbonne Paris Cité (CRESS), Paris Descartes University, Villejuif, France; g Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. Environment International DOI: https://doi.org/10.1016/j.envint.2018.05.007
