Tag Archives: Press release

Compensation mechanisms in subjects with Alzheimer’s disease lesions to preserve their intellectual and memory performance

The INSIGHT-preAD study, directed by Prof. Bruno Dubois, is being carried out by teams from Inserm, CNRS and Université Sorbonne at the Brain and Spine Institute (ICM) and the Memory and Alzheimer’s Disease Institute (IM2A) at AP-HP Pitié-Salpêtrière Hospital in Paris, in collaboration with the MEMENTO cohort. It aims at identifying factors underlying Alzheimer’s disease development in healthy subjects over 70 with no existing cognitive disorders.
Sponsored by Inserm, this study shows that after 30 months of follow-up, amyloid lesions (also called Alzheimer’s lesions) did not impact cognition or behavior in affected subjects.
Its results, published on February 27, 2018, in The Lancet Neurology, point to the existence of compensatory mechanisms in subjects with these lesions.

Posted in Press releases, Neurosciences, cognitives sciences, neurology and psychiatry | Tagged | Comments closed

Alcoholism and dementia risk

Excessive alcohol consumption is linked to a threefold increase in overall dementia risk and a twofold increase in that of developing Alzheimer’s disease, making it a major modifiable risk factor for these conditions. This is the conclusion of an Inserm study performed in collaboration with Canadian researchers via the QalyDays Study Group . Using exhaustive data on hospitalizations in France between 2008 and 2013, the researchers studied the link between alcoholism and dementia. Their findings, published in The Lancet Public Health, confirm the importance of reinforcing measures to prevent the misuse of alcohol.

Posted in Press releases, Public health | Tagged | Comments closed

Flunarizine: a New Drug Candidate in the Treatment of Spinal Muscular Atrophy

A team of researchers from Inserm (“Toxicology, pharmacology and cell signaling” JRU 1124) and the universities of Paris Descartes and Paris Diderot have recently discovered that flunarizine – a drug already used to treat migraine and epilepsy – enables the repair of a molecular defect related to spinal muscular atrophy, a severe and incurable disease. This discovery is the culmination of research efforts ongoing since 1995, when the Inserm team – comprising Suzie Lefebvre, leader of the current research projects – identified the gene responsible for infantile spinal muscular atrophy. The results of the initial animal tests, published in Scientific Reports, demonstrate a marked improvement in health. These extremely promising findings must now be confirmed in humans.

Posted in Molecular and structural bases of living organisms, Press releases, Genetics, genomics and bioinformatics, Health technologies | Tagged | Comments closed

A new gene implicated in hypertension

A team of researchers led by Maria-Christina Zennaro, Inserm research Director at the Paris Cardiovascular Research Center (Inserm/ Paris-Descartes University), in collaboration with German colleagues , has identified a new gene implicated in hypertension. This study has been published in Nature Genetics.

These new findings highlight the role of genetic predisposition in the onset of common diseases and the importance of the French Plan for Genomic Medicine 2025. A plan in which one objective is to enable access to genetic screening, even for common diseases, in order to provide personalized medical care.

Posted in Press releases, Genetics, genomics and bioinformatics | Tagged | Comments closed

Type 1 diabetes: the role of the thymus is not what we thought!

A small revolution has taken place in the world of type 1 diabetes research. A study conducted by an Inserm team led by Roberto Mallone at the Cochin Institute (Inserm, CNRS, Paris Descartes University) is calling into question the role long attributed to the thymus in selecting and eliminating white blood cells associated with type 1 diabetes and reveals that we are all auto-immune. Discoveries which change our understanding of the mechanisms of type 1 diabetes and point to new therapeutic strategies in fighting this disease. 

This research has been published in Science Immunology. 

Posted in Press releases, Immunology, inflammation, infectiology and microbiology | Tagged | Comments closed

Consumption of ultra-processed food and risk of cancer

A new study bringing together researchers from Inserm, Inra and University of Paris 13 (Center of Research in Epidemiology and Statistics Sorbonne Paris Cité, EREN team) suggests a link between the consumption of ultra-processed food and the additional risk of developing cancer. In total, 104,980 participants from the French NutriNet-Santé cohort were included. During the follow-up period (8 years), 2,228 cases of cancer were diagnosed and validated. A 10% increase in the proportion of ultra-processed foods in the diet was associated with a greater than 10% increase in the risk of overall cancer and, more specifically, breast cancer. Out of the various hypotheses which could explain these findings, the generally poorer nutritional quality of ultra-processed food may not be the only contributing factor, thereby pointing to mechanisms involving other compounds (additives, substances formed during industrial processes, materials in contact with food, etc.). These findings, which must therefore be considered as an initial avenue of investigation in this area, need to be confirmed in other study populations. The causal relationship in particular remains to be proven. This study was published on February 15, 2018 in the British Medical Journal.

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A novel high-performance and non-invasive hybrid medical imaging technique

The rapidly-developing medical imaging field could well have found a novel technique in which multiple facets of a living being can be observed in real time and non-invasively. Teams from the Langevin Institute (ESPCI Paris – PSL University / CNRS), the biomedical ultrasound Technology Research Accelerator (Inserm A.R.T.) and the Paris-Cardiovascular Research Center (Inserm / Paris Descartes University) have developed a new medical imaging instrument which combines positron emission tomography – Pet-scan* – with ultrafast ultrasound imaging. Named PETRUS, the acronym of Positron Emission Tomography Registered Ultrafast Sonography, it has obtained 3D images in which organ anatomy, metabolism, function and even elasticity are perfectly superimposed. This research made the cover of the February 6 issue of Nature Biomedical Engineering.

Posted in Press releases, Circulation, metabolism, nutrition, Health technologies | Tagged | Comments closed

The Biological Clock Sets a Different Rhythm for Each Organ

A team of Inserm researchers led by Howard Cooper (Inserm Unit 1208 “Stem Cell and Brain Institute”) in collaboration with their colleagues in the U.S. have for the first time established a reference map of gene expression, by organ and time of day. A mammoth task that began a decade ago and has required two years of analysis. These results, published in Science, show just how important it is to consider the biological clock in order to administer medication at the right time for optimized efficacy and minimal side effects. The researchers are now preparing an atlas which will be available for use by the entire scientific community.

Posted in Press releases, Neurosciences, cognitives sciences, neurology and psychiatry | Tagged | Comments closed

Migraine: Regions of the Brain We Thought Felt No Pain

Could we have been wrong over the past 70 years in thinking that certain regions of the brain are insensitive to pain? This is what the findings of a team of researchers from Inserm, Nice University Hospital, Université Côte d’Azur and St Anne Hospital in Paris would suggest. By collecting observations of brief painful events occurring during brain surgery in awake patients, they found that certain structures – hitherto considered not to feel pain – were at the origin of pain sensations when stimulated mechanically. These findings, to be published shortly in Brain, open up new avenues for research into the treatment of headache and, in particular, migraine.

Posted in Press releases, Neurosciences, cognitives sciences, neurology and psychiatry | Tagged | Comments closed

Clever bacteria put human ingenuity to the test

How do bacteria manage to infect our body? What tactics do they use to slip through the cracks in our immune system? This is what the team of Thomas Henry, Inserm researcher, and his coworkers from the CNRS of Claude Bernard Lyon 1 University and the École Normale Supérieure de Lyon grouped within the International Center for Infectiology Research (CIRI) are trying to elucidate. In a paper published in Nature Communication, the researchers studied a key component in the escape mechanism of bacteria and found, in humans, the major player involved in its detection.

Posted in Press releases, Immunology, inflammation, infectiology and microbiology | Tagged | Comments closed
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