Tag Archives: Press release

New Antiviral Targets Identified to Combat Dengue

The dengue virus – like all other viruses – hijacks many of the host cell’s functions to accomplish its infectious cycle. For the very first time, researchers from Inserm, CNRS and Université Paris Diderot have recently identified all of the cellular factors that interact with the virus as it replicates. By providing proof of concept that some of these molecules can be inhibited, these scientists are paving the way for new antiviral therapies for dengue and also for other viruses in the same family, such as the Zika and West Nile viruses.

Posted in Press releases, Immunology, inflammation, infectiology and microbiology | Tagged | Comments closed

Could the Biological Clock Be a Key Ally in the Fight Against Inflammatory Disease?

What if the symptoms and seriousness of certain inflammatory diseases were linked to time of day? Researchers from Inserm, Institut Pasteur de Lille and Université de Lille[1] have been working on this hypothesis, after noting that the seriousness and mortality associated with fulminant hepatitis were dependent on the time at which the disease was induced. Their study, conducted on human cells and mice, shows that the anti-inflammatory action of a biological clock protein could prevent the onset of fulminant hepatitis, by alleviating symptoms and increasing survival rates.

Posted in Press releases, Circulation, metabolism, nutrition | Tagged | Comments closed

Beware of Sustained Ibuprofen Use in Men

A recent study conducted by Inserm researchers within Irset[1] has shown that sustained ibuprofen use in young male athletes induces a hormonal imbalance known as “compensated hypogonadism”, usually observed in elderly males. This situation arises due to the negative effects of ibuprofen on testosterone production, and on the production of two other testicular hormones. These results have been published in Proceedings of the National Academy of Sciences.

Posted in Press releases, Circulation, metabolism, nutrition, Public health | Tagged | Comments closed

Des puces pour modéliser et mieux comprendre la maladie de Huntington

En combinant l’utilisation de neurones issus de souris modèles de la maladie de Huntington, une maladie neurologique d’origine génétique, et la technologie microfluidique, l’équipe de Frédéric Saudou, Directeur de Grenoble Institut des Neurosciences (GIN – Inserm/UGA) et responsable de l’équipe « Dynamiques intracellulaires et neurodégénérescence », en collaboration avec Benoit Charlot, de l’Institut d’électronique des systèmes (CNRS/Université de Montpellier), a reconstitué sur une puce le circuit neuronal atteint chez les patients. Cette étude qui a permis d’identifier un nouveau mécanisme pathogénique, a été publiée dans la revue Cell Reports le 2 janvier 2018.

Posted in Press releases, Neurosciences, cognitives sciences, neurology and psychiatry | Tagged | Comments closed

An international study identifies new loci associated with asthma wich are enriched in epigenetic marks

An international study led by scientists from Inserm and Paris Diderot University (France), the University of Chicago (USA), the National Heart and Lung Institute (UK) and the University of Colorado Anschutz Medical Campus (USA) together with researchers of the Trans-National Asthma Genetics Consortium (TAGC) has discovered five new regions of the genome that increase the risk of asthma. This study is published online in Nature Genetics on 22 December 2017.

Posted in Press releases, Public health | Tagged | Comments closed

Microbiome Influences Brain’s Immune Cells in a Sex and Age-dependent manner

A joint study conducted by Inserm researchers from IBENS (Institute of Biology of the Ecole Normale Supérieure – Inserm/CNRS/ENS Paris) in Paris and researchers from SIgN (Singapore Immunology Network, A*STAR) in Singapore has revealed a hitherto undiscovered role played by the microbiota on immune cells in the brain, occurring from the fetal stage. These cells, known as microglia, play a key role in brain development and function, and are affected in different ways by changes in the microbiota in male and female mice at different stages of their lives. The results of this research have been published in Cell.

Posted in Cell biology, development and evolution, Press releases | Tagged | Comments closed

The first French cell therapy trial in a form of retinitis pigmentosa on the horizon

A team of scientists led by Christelle Monville (professor at University of Evry) at I-Stem, the laboratory created by AFM-Téléthon, University of Evry and Inserm, in partnership with the team led by Olivier Goureau, Inserm Research Director within the Institute of Vision, has managed to improve vision in rats with retinitis pigmentosa, by transplanting a cell bandage obtained from human embryonic stem cells. The results published today in Science Translational Medicine, notably achieved thanks to Téléthon donations, pave the way for cell therapy retinitis pigmentosa, but also for very common retinal degenerative diseases, such as certain forms of age-related macular degeneration (AMD).

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A new therapeutic target in allergic asthma

Vincent Sauzeau, Inserm researcher and his team located at the Nantes Thorax Institute[1] (Inserm, CNRS, University of Nantes, Nantes University Hospital) have recently discovered the major role played by the Rac1 protein in the development of bronchial hyperresponsiveness associated with allergic asthma. Researchers will use this new therapeutic target to reduce bronchoconstriction and pulmonary inflammation in patients. This article has been published in The Journal of Allergy and Clinical Immunology.

Posted in Press releases, Circulation, metabolism, nutrition | Tagged | Comments closed

What does science say about the eleven vaccines that will be mandatory for all children in France starting in 2018? INSERM has just published an official report.

In the context of the extension of mandatory vaccination that will go into effect in 2018, immunization is becoming a topic of public debate. People are often ill-informed, basing their opinions on the catastrophist arguments of anti-vaccine lobbies and the lack of relevant training on the part of medical professionals. France has become one of the countries where defiance against vaccination is at its strongest worldwide. The controversy is happening despite the facts that the mandatory vaccinations match the current immunization calendar and that no additional vaccines have been added. The purpose of this measure is to ensure that children are actually receiving the vaccines that are scheduled for all children.

Posted in Press releases, Institutional and special event | Tagged | Comments closed

Identification of Early Markers of Neurodegenerative Diseases in At-risk People

A study sponsored by the AP-HP has shown for the first time that asymptomatic individuals who carry the c9orf72 mutation, which means they are at risk of developing frontotemporal degeneration (FTD) or amyotrophic lateral sclerosis (ALS), experience cognitive, anatomical, and structural changes very early on, before age 40.

The ability to identify these markers before disease symptoms appear is a major discovery, as such markers are crucial in developing therapeutic trials and monitoring their efficacy.

Posted in Press releases, Neurosciences, cognitives sciences, neurology and psychiatry | Tagged | Comments closed
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