Tag Archives: Press release

Behind a Rare Disease: A Gut Sensitive to the Cold and Intolerant of its Own Bacteria

A mechanism of tolerance towards intestinal flora is thought to be implicated in the onset of a rare familial autoinflammatory disease induced by cold temperatures. This is the finding of researchers from the Center for Infection and Immunity of Lille (Inserm/Université de Lille/CNRS/University Hospital Lille/Institut Pasteur de Lille), the Pathophysiology of Pediatric Genetic Diseases laboratory (Inserm/Sorbonne Université) and the Department of Immunology at the University of Hohenheim. Their research, published in Nature Communications, reveals the implication in its onset of an exacerbated inflammatory response against the gut flora, making for a more effective immune response against certain pathogens.

Posted in Press releases, Immunology, inflammation, infectiology and microbiology | Tagged | Comments closed

Expertise caregivers helps improve patient diagnosis in altered state of consciousness

Hospital teams Pitié-Salpêtrière Hospital AP-HP, Inserm and the Institute of the brain and spinal cord – AP-HP / CNRS / Inserm / University-Sorbonne showed appreciation caregivers (nurses and nursing auxiliaries) for the state of consciousness of patients represented a real added value to medical and electrophysiological exams and conventional brain imaging diagnostics.

Posted in Press releases, Neurosciences, cognitives sciences, neurology and psychiatry | Tagged | Comments closed

Syndrome Temple and Silver Russell understanding of epigenetic mechanisms regulating fetal growth

A team Sorbonne / AP-HP / Inserm, led by Professor Irene Netchine, physiology professor at Sorbonne University and pediatrician at the Hospital Armand Trousseau AP-HP, studied the molecular mechanisms of the clinical similarity between syndrome Temple and Russell Silver syndrome. Their study, published in Science Advances , highlights the importance of gene network concept “imprinted” in the diagnosis and treatment of patients with these rare syndromes.

Posted in Press releases, Circulation, metabolism, nutrition | Tagged | Comments closed

Successful In Utero Hematopoietic Stem Cell Transplantation in a Fetus with Severe Combined Immunodeficiency

Teams from the Biological Therapy Department and Pediatric Immunohematology Unit at Necker-Enfants Malades Hospital AP-HP, the Fetal Medicine Department at Trousseau Hospital AP-HP, Inserm, the Imagine Institute, Université Paris Descartes and Sorbonne Université have achieved the in utero transplantation of hematopoietic stem cells in a fetus with X-linked severe combined immunodeficiency.

Posted in Press releases, Immunology, inflammation, infectiology and microbiology | Tagged | Comments closed

A nanomedicine which relieves pain without the risk of addiction

A painkiller nanomedicine has just been developed by Patrick Couvreur’s team at Institut Galien Paris-Sud (Université Paris-Sud/CNRS). This new drug specifically targets the area of painful inflammation without causing the addiction phenomena of current medication.

Posted in Press releases, Neurosciences, cognitives sciences, neurology and psychiatry | Tagged | Comments closed

Direct-acting antivirals: confirmation of their short-term clinical efficacy in “real life”

A study published in The Lanceton 11 february 2019shows that direct-acting antivirals have short-term clinical benefits in the treatment of hepatitisCvirusinfection. These results come from ANRS-funded interdisciplinary research conducted byclinicians,hepatologists, and epidemiologistsof theInserm, SorbonneUniversityand AP-HPandcoordinatedby ProfessorsFabrice CarratandStanislas Pol,and Dr Hélène Fontaine,1in9895 patientsof the ANRS CO 22 HEPATHERnational cohortrecruitedin 32 centers in France.

Posted in Press releases, Immunology, inflammation, infectiology and microbiology | Tagged | Comments closed

When HIV Uses Camouflage to Evade the Immune System

How is HIV able to escape the surveillance of the immune system within the very cells it infects? Researchers from Inserm, CNRS, Université de Montpellier and Université de Lorraine decided to take a closer look at one of these evasion mechanisms. They were able to observe the ability of HIV to “camouflage” its RNA within the infected cell using an intracellular enzyme. This research, published in Nature, provides new knowledge on the evasion mechanisms of HIV in the face of the innate immune system.

Posted in Press releases, Immunology, inflammation, infectiology and microbiology | Tagged | Comments closed

Alzheimer’s: identification of potential target protein aggregates for treating the disease

La propagation des agrégats de la protéine Tau dans le cerveau contribue à la progression de la maladie d’Alzheimer. Des chercheurs du Laboratoire des maladies neurodégénératives : mécanismes, thérapies, imagerie (CNRS/CEA/Université Paris-Sud, MIRCen), en collaboration avec l’Ecole normale supérieure, Sorbonne Université et l’Inserm, viennent d’identifier les cibles de ces agrégats. Publiés dans EMBO Journal le 10 janvier 2019, ces travaux permettront la conception d’outils capables de bloquer ces éléments clés dans la propagation des agrégats et de contrecarrer ainsi leur effet pathologique.

Posted in Cell biology, development and evolution, Press releases, Genetics, genomics and bioinformatics, Neurosciences, cognitives sciences, neurology and psychiatry | Tagged | Comments closed

Discovery of novel mechanisms that cause migraines

Researchers at CNRS, Université Côte d’Azur and Inserm have demonstrated a new mechanism related to the onset of migraine. In fact, they found how a mutation, causes dysfunction in a protein which inhibits neuronal electrical activity, induces migraines. These results, published in Neuron on December 17, 2018, open a new path for the development of anti-migraine medicines.

Posted in Cell biology, development and evolution, Genetics, genomics and bioinformatics, Neurosciences, cognitives sciences, neurology and psychiatry | Tagged | Comments closed

Myopathie : un gain de force musculaire chez la souris

Des souris atteintes de dystrophie musculaire de Duchenne récupèrent plus de 20% de force musculaire grâce à la metformine.

Posted in Cell biology, development and evolution, Press releases | Tagged | Comments closed
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