Article publié dans la revue Science
Anticancer immunotherapy by CTLA4 blockade relies on the gut microbiota
Marie Vétizou1,2,3, Jonathan M. Pitt1,2,3, Romain Daillère1,2,3, Patricia Lepage5, Nadine Waldschmitt13, Caroline Flament1,2,4, Sylvie Rusakiewicz1,2,4, Bertrand Routy1,2,3, Maria P. Roberti1,2,4, Connie PM. Duong1,2,4, Vichnou Poirier-Colame1,2, Antoine Roux1,2,19, Sonia Becharef1,2,4, Silvia Formenti6, Encouse Golden6, Sascha Cording7, Gerard Eberl7, Andreas Schlitzer8, Florent Ginhoux8, Sridhar Mani12, Takahiro Yamazaki1,2, Nicolas Jacquelot1,2,3, David P. Enot1,10, Marion Bérard23, Jérôme Nigou14,15, Paule Opolon1, Alexander Eggermont1,2,16, Paul-Louis Woerther17, Elisabeth Chachaty17, Nathalie Chaput1,26, Caroline Robert1,16,24, Christina Matteus1,16, Guido Kroemer9,10,11,18,19, Didier Raoult20, Ivo Gomperts Boneca21,22†, Franck Carbonnel3,25†, Mathias Chamaillard13† , and Laurence Zitvogel1,2,3, 4*
1 Institut de Cancérologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France.
2 Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, GRCC, Villejuif, France.
3 University of Paris Sud XI, Kremlin Bicêtre, France.
4 Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 1428, Villejuif, France.
5 Institut National de la Recherche Agronomique (INRA), Micalis-UMR1319, 78360 Jouy-en-Josas, France.
6 Department of Radiation Oncology, New York University, New York, NY, USA.
7 Microenvironment & Immunity Unit, Institut Pasteur, Paris, France.
8 Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore;
9 INSERM U848, Villejuif, France.
10 Metabolomics Platform, GRCC, Villejuif, France.
11 Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138, Paris, France.
12 Departments of Genetics and Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
13 Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 – UMR 8204 – CIIL - Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France.
14 Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale (IPBS), Toulouse, France.
15 Université de Toulouse, Université Paul Sabatier, IPBS, F-31077 Toulouse, France.
16 Department of Medical Oncology, IGR, Villejuif, France.
17 Service de microbiologie, GRCC, Villejuif, France.
18 Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.
19 Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
20 Unité des Rickettsies, Faculté de Médecine, Université de la Méditerranée, Marseille, France.
21 Institut Pasteur, Unit Biology and Genetics of the bacterial Cell Wall, Paris, France.
22 INSERM, Equipe Avenir, Paris, France.
23 Animalerie Centrale, Institut Pasteur, Paris, France.
24 Institut National de la Santé Et de la Recherche Medicale (INSERM) U981, GRCC, Villejuif, France.
25 Gastroenterology department Hôpital Bicêtre APHP, Paris, France
26 Laboratory of immunomonitoring in oncology (L.I.O), UMS 3655 CNRS / US 23 INSERM, GRCC, Villejuif, France.