Grâce à une importante analyse génomique des cancers du foie de l'enfant, l'équipe du Professeure Jessica Zucman-Rossi au Centre de Recherche des Cordeliers (Université de Paris, Inserm, Sorbonne Université), et ses collaborateurs du réseau Hepatobio, ont identifié de nouveaux mécanismes de résistance à la chimiothérapie.
Certains pesticides utilisés en Europe sont suspectés d’avoir des effets néfastes sur la santé humaine. Ils provoqueraient des perturbations hormonales et auraient également des propriétés carcinogènes, déjà observées en milieu professionnel. Le lien entre l’exposition à ces pesticides via l’alimentation et le cancer du sein dans la population générale est encore peu étudié.
Monoclonal antibodies are part of the therapeutic arsenal for eliminating cancer cells. Some make use of the immune system to act and belong to a class of treatment called "immunotherapies." But how do these antibodies function within the tumor? And how can we hope to improve their efficacy?
Les données d'une nouvelle étude confirment que le traitement par hormone de croissance suite à une radiothérapie chez les enfants qui présentent un déficit de cette hormone n’augmente pas le risque de survenue d’un second cancer.
Until now considered highly promising in the fight against aging, the therapeutic strategy of eliminating the senescent cells that accumulate in the body is being challenged by the team of Dmitry Bulavin, Inserm researcher at the Institute for Research on Cancer and Aging of Nice (Inserm/CNRS/Université Côte d’Azur).
An ordinary edible mushroom could be a game-changer when it comes to the treatment of rare genetic diseases. These affect hundreds of millions of people worldwide who often find themselves powerless in the absence of effective therapy. A team of researchers has shown that an active ingredient contained in the Lepista inversa mushroom has repair properties, making it possible to correct certain genetic mutations, known as "nonsense" mutations.
Using in vivo imaging tools, scientists from the Institut Pasteur and Inserm described the spatiotemporal activity of tumor-infiltrating T lymphocytes, both locally and remotely.
Does the blood we thought to know so well contain elements that had been undetectable until now? The answer is yes, according to a team of researchers which has revealed the presence of whole functional mitochondria in the blood circulation. These organelles that are responsible for cellular respiration had hitherto only been found outside cells in very specific cases.
Glioblastomas are the most common type of brain tumor, and their prognosis is often highly unfavorable. A collaborative study by Jean-Léon Thomas, Inserm researcher at the Brain & Spine Institute (Inserm/CNRS/Sorbonne Université) and Pitié-Salpêtrière Hospital AP-HP, and Akiko Iwasaki (Department of Immunology, Yale University School of Medicine, USA), has revealed the beneficial role played by the meningeal lymphatic vascular network in treating these tumors – in the short and...
An international team led by Wolf Hervé Fridman with researchers from Inserm, Sorbonne Université and Université de Paris at the Cordeliers Research Center, in collaboration with the French League against cancer and Institut Bergonié, has shown that B cells also play a major role in predicting of patient’s response to immunotherapy. It was previously thought only T cells could be used in this way.