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CLOVES Syndrome : European Medicines Agency grants marketing authorisation for alpelisib

Aalpelisib has now been approved by the European Medicines Agency for the treatment of severe forms of PIK3CA-related overgrowth spectrum (PROS), including CLOVES syndrome. This therapeutic breakthrough is the result of the work carried out by Professor Guillaume Canaud and his team within the Translational Medicine and Targeted Therapies Unit at Université Paris Cité, Necker-Enfants Malades Hospital AP-HP, and Inserm.

16 Jun 2026 | Genetics, genomics and bioinformatics Immunology, inflammation, infectiology and microbiology

Scientists have succeeded in creating larger intestinal organoids with a functional nervous system

More and more people are suffering from gastrointestinal diseases. To better understand these conditions and provide solutions for patients, scientists are working on organoids, small three-dimensional biological structures capable of replicating certain functions of an organ. These models are valuable tools for studying cell development and disease mechanisms. A team from Inserm and the University of Nantes, in collaboration with American teams, has developed a new culture method that,...

15 Jun 2026 | Circulation, metabolism, nutrition

From precancerous lesions to colorectal cancer: shedding light on unexpected biological mechanisms

The prevention of colorectal cancer relies on the early detection and removal of precancerous lesions, which can significantly reduce the risk of progression to invasive cancer. However, the immune mechanisms involved in these lesions remain poorly understood. A research team from Inserm, Sorbonne University, and Paris Cité University has identified an association between immune activity in the microenvironment of precancerous lesions, the frequency of polyp development, and the risk...

10 Jun 2026 | Cancer

Food colourings and preservatives: Three new studies point to links between food additives and an increased risk of cancer, type 2 diabetes, cardiovascular disease, and hypertension

Among the 3.5 million food and beverage items listed in the Open Food Facts World database in 2024, more than 139,000 contain at least one food colouring additive and more than 700,000 contain at least one preservative. Three new studies show links between the consumption of these additives and an increased risk of cancer, type 2 diabetes, cardiovascular disease, and hypertension. This research is conducted by a team of...

21 May 2026 | Cancer Circulation, metabolism, nutrition Public health

Démangeaisons et inflammation de la peau : l’implication étonnante de nos neurones

Les troubles dermatologiques sont caractérisés par une inflammation et des démangeaisons sévères, et les traiter ainsi que les soulager représentent un véritable défi pour la recherche. Une équipe de l’Inserm, du CNRS et de l’Université de Toulouse, a montré que dans la dermatite de contact, deux catégories de nocicepteurs avaient des fonctions biologiques distinctes. En effet, l’une permettrait de réguler les démangeaisons, tandis que l’autre semble agir directement sur...

04 May 2026 | Immunology, inflammation, infectiology and microbiology

Intra-tumour immunotherapy: mobilising the immune system against cancer while avoiding toxicity to the body

Published in the journal Nature, the NIVIPIT study, led by Gustave Roussy and conducted by researchers from Inserm and the University of Paris-Saclay, demonstrates the benefit — in terms of both efficacy and safety — of administering an immunotherapy treatment intratumorally that is typically given intravenously. This approach, carried out via interventional radiology — a field in which Gustave Roussy is a leading actor — involves injecting the treatment...

30 Apr 2026 | Cancer

Pancreatic cancer: an antibody proves itself in an early clinical trial

Pancreatic cancer, which affects a growing number of patients, remains one of the most aggressive forms due to the ability of cancer cells to resist traditional treatments such as chemotherapy.

27 Apr 2026 | Cancer Immunology, inflammation, infectiology and microbiology

A major international clinical trial sheds new light on a paediatric brain cancer

BIOMEDE 1.0, sponsored and coordinated by Gustave Roussy, is the largest clinical trial ever conducted in diffuse intrinsic pontine glioma, an aggressive paediatric cancer in which survival rarely exceeds one year. The findings, published in the journal Nature Medicine, chart a new biological map of the disease, identify patient response biomarkers, and document the prolonged survival of four children — opening concrete avenues for the therapies of tomorrow. This...

24 Apr 2026 | Cancer

Using fewer cosmetics quickly reduce exposure to certain chemical pollutants and endocrine disruptors, such as bisphenol A

Using fewer cosmetics and skincare products can quickly reduce exposure to several chemicals, including known or suspected endocrine disruptors, according to a study published on April 7 in Environment International by researchers from Inserm, the University of Grenoble Alpes, and the CNRS, at the Institute for the Advancement of Biosciences, and supported by the European Commission.

22 Apr 2026 | Public health

Alzheimer’s: discovery of the involvement of new cells in the onset and progression of the disease

Patients with Alzheimer's disease have common biological alterations, including abnormal accumulation of the Tau protein in the brain. The mechanisms behind this abnormality may be on the verge of being elucidated. In a new study, a research team from Inserm, the University of Lille, and Lille University Hospital has revealed for the first time the role of tanycytes in the equation.

05 Mar 2026 | Neurosciences, cognitives sciences, neurology and psychiatry

When sleep apnea causes metabolic jet lag

Sleep apnea affects nearly one billion people worldwide and causes repeated episodes of oxygen deprivation during the night, known as intermittent hypoxia. A study conducted by scientists from the University of Grenoble Alpes, Inserm, and Grenoble Alpes University Hospital, published today in the journal Science Advances, shows that these episodes reorganize the liver's biological clock, altering the daily rhythms of its metabolic activity.

25 Feb 2026 | Circulation, metabolism, nutrition

In Paris, trees reduce mortality linked to heat waves

In Paris, districts with more vegetation have a lower risk of death during periods of high heat, while highly mineralized areas with few green spaces and a high potential for urban heat islands are the most exposed.The scientists emphasize the importance of developing vegetation in cities and better distributing green spaces among neighborhoods to protect the health of Parisians in the face of global warming.

16 Feb 2026 | Public health

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