Blood stem cells have a surprising ability. In addition to ensuring the continuous renewal of blood cells, they keep track of past infections so that faster and more effective immune responses can be triggered in the future.
Teams from Dijon-Bourgogne University Hospital, Inserm and CEA have recently established the results of the whole-genome analysis of severely ill neonates, hospitalized in neonatal ICUs – the time of which was slashed from the current 18-month average to just 38 days.
Les recherches sur l’origine génétique des troubles du spectre de l’autisme (TSA) se sont significativement développées ces dernières années. Cependant, de nombreux patients concernés n’en bénéficient pas encore systématiquement. Une étude met en évidence l’intérêt d’étendre le dépistage génétique à un nombre plus important de patients souffrant de TSA avec déficit intellectuel.
Inserm and CNRS researchers from the Institute of Genetics and Molecular and Cellular Biology (Inserm/CNRS/Université de Strasbourg) have discovered how myotubularin - a protein deficient in myotubular myopathy - interacts with amphiphysin 2 and suggest targeting the latter in order to treat patients.
In collaboration with the universities of Miami, Columbia and San Francisco, scientists from the Institut Pasteur, Inserm, CNRS, Collège de France, Sorbonne University and the University of Clermont Auvergne have managed to restore hearing in an adult mouse model of DFNB9 deafness – a hearing disorder that represents one of the most frequent cases of congenital genetic deafness. Individuals with DFNB9 deafness are profoundly deaf as they are deficient...
La propagation des agrégats de la protéine Tau dans le cerveau contribue à la progression de la maladie d’Alzheimer. Des chercheurs du Laboratoire des maladies neurodégénératives : mécanismes, thérapies, imagerie (CNRS/CEA/Université Paris-Sud, MIRCen), en collaboration avec l’Ecole normale supérieure, Sorbonne Université et l’Inserm, viennent d’identifier les cibles de ces agrégats. Publiés dans EMBO Journal le 10 janvier 2019, ces travaux permettront la conception d’outils capables de bloquer ces éléments clés...
Researchers at CNRS, Université Côte d’Azur and Inserm have demonstrated a new mechanism related to the onset of migraine. In fact, they found how a mutation, causes dysfunction in a protein which inhibits neuronal electrical activity, induces migraines. These results, published in Neuron on December 17, 2018, open a new path for the development of anti-migraine medicines.
As tumors develop, they evolve genetically. How does the immune system act when faced with tumor cells? How does it exert pressure on the genetic diversity of cancer cells? Scientists from the Institut Pasteur and Inserm used in vivo video techniques and cell-specific staining to visualize the action of immune cells in response to the proliferation of cancer cells. The findings have been published in the journal Science Immunology...
Asymmetry plays a major role in biology at every scale: think of DNA spirals, the fact that the human heart is positioned on the left, our preference to use our left or right hand … A team from the Institute of biology Valrose (CNRS/Inserm/Université Côte d’Azur), in collaboration with colleagues from the University of Pennsylvania, has shown how a single protein induces a spiral motion in another molecule. Through...
Teams of rheumatology, respiratory medicine, genetics and the university hospital department FIRE Hospital Bichat Claude Bernard AP-HP, in collaboration with INSERM, Université Paris Diderot, the Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA, have discovered that a rare allele of rs35705950 variant gene MUC5B multiply by six the risk of occurrence of pulmonary fibrosis in patients with rheumatoid arthritis (RA). This broad study of genetic association...
