A team at the Institut de Génétique et de Biologie Moléculaire et Cellulaire has evidenced, at the atomic scale, the threedimensional structure of the complete human ribosome and the detailed interactions that occur within it.
Researchers from the CNRS, Inserm and the Université de Montpellier and Université Jean Monnet - Saint-Étienne have developed a new approach for preventing the destructive activity of osteoclasts without affecting their viability.
A team of researchers from Inserm led by Fanny Mochel and located at the Brain and Spinal Cord Institute (Inserm/CNRS/UPMC/AP-HP) has just demonstrated the therapeutic potential of triheptanoin in ten patients with Huntington’s disease.
An international collaboration coordinated by the German Cancer Research Center (DKFZ) (University of Heidelberg), including French researchers from the Institute of Genetics and Development of Rennes (IGDR) (CNRS/University of Rennes 1) under the leadership of Gwenaël Rabut, Inserm Researcher, and teams from Sweden and Canada, has just demonstrated a new molecular mechanism that may allow cells to destroy proteins accidentally localised to the nucleus.
A group of scientists in Strasbourg has demonstrated that one of the 80 components of each ribosome is essential for infection by certain viruses without being necessary for normal cell functioning.
By studying the mode of action of the interleukin-33 protein, an alarmin for white blood cells, a team at the Institut de Pharmacologie et de Biologie Structurale (IPBS - CNRS/Université Toulouse III - Paul Sabatier) has been able to evidence truncated forms of the protein that act as potent activators of the cells responsible for triggering allergic reactions.
Consuming oils rich in polyunsaturated fatty acids, especially 'omega 3', is good for our health. But the mechanisms explaining these effects are poorly understood. Researchers from the Institute of Molecular and Cellular Pharmacology (CNRS/Nice Sophia Antipolis University), the Compartmentation and Cellular Dynamics Unit (CNRS/Curie Institute/UPMC) of Inserm and Poitiers University1 were interested in the effect of lipids carrying polyunsaturated chains when they are taken into cell membranes.
Des chercheurs strasbourgeois du laboratoire Biotechnologie et signalisation cellulaire de l'École Supérieure de Biotechnologie de Strasbourg (CNRS/Université de Strasbourg) et de l’Institut de génétique et de biologie moléculaire et cellulaire (CNRS/Université de Strasbourg/Inserm) ont résolu, pour la première fois, la structure tridimensionnelle d’une oncoprotéine majeure, impliquée dans la prolifération cellulaire et à l’origine du développement du papillomavirus humain. Celui-ci, de type 16 (HPV 16), est le plus dangereux...
Despite progress in regenerative medicine, with age, the skin loses its properties in an irreversible manner. The ATIP-Avenir team "Epidermal homeostasis and tumorigenesis" directed by Chloé Féral, an Inserm researcher at the French Cancer and Aging Research Institute (Inserm/CNRS/Université Sophia Antipolis), has just defined the cellular and molecular mechanisms involved in maintaining skin cells and skin healing in advanced years. These mechanisms, described in vivo in mice, engage molecule...
Bisphenol A (BPA), which is present to a great extent in our domestic environments, is suspected of inducing hormonal effects in humans.