Restoring the action of insulin is one of the keys to fighting type 2 diabetes. Researchers from Inserm led by Dominique Langin at the Institute of Cardiovascular and Metabolic Diseases (Inserm/Université de Toulouse) are developing a therapeutic strategy that uses the properties of an enzyme (hormone-sensitive lipase) which, when stimulating fatty-acid synthesis in the fat cells, has a beneficial effect on insulin action. This research has been published in...
This year’s Inserm Prize ceremony will take place on Tuesday December 11, 2018, at the Collège de France in celebration of nine researchers and engineers whose achievements have helped raise the level of scientific excellence at the Institute, in the service of science for health. "By honoring its talents, Inserm wishes to showcase the diversity and richness of the biomedical research professions, and the creativity and passion of the...
Gilles Bloch has been appointed Chairman and Chief Executive Officer of the French National Institute of Health and Medical Research (Inserm) by the Council of Ministers.
As tumors develop, they evolve genetically. How does the immune system act when faced with tumor cells? How does it exert pressure on the genetic diversity of cancer cells? Scientists from the Institut Pasteur and Inserm used in vivo video techniques and cell-specific staining to visualize the action of immune cells in response to the proliferation of cancer cells. The findings have been published in the journal Science Immunology...
Asymmetry plays a major role in biology at every scale: think of DNA spirals, the fact that the human heart is positioned on the left, our preference to use our left or right hand … A team from the Institute of biology Valrose (CNRS/Inserm/Université Côte d’Azur), in collaboration with colleagues from the University of Pennsylvania, has shown how a single protein induces a spiral motion in another molecule. Through...
The findings, published in the journal Gastroenterology in November 2018, show that if the liver cancer risk is greatly reduced after viral eradication in these patients, it still persists and justified to keep patients with viral cirrhosis C cured in screening programs. This study also confirms the benefits of virologic cure the risk of hepatic carcinogenesis regardless of the type of antiviral treatment.
Researchers from Inserm, CNRS, Paris-Sud University, Gustave Roussy, and Institut Curie have identified a new agent in regulating PD-L1 gene expression: the eIF4F complex, which plays a role in controlling protein synthesis.
As part of the InFoR-Autism* scientific program, supported by Institut Roche, an MRI neuroimaging study investigated the links between local anatomical connectivity and social cognition in individuals with autism spectrum disorder (ASD).
A research team from CNRS, Université PSL, the Collège de France and Inserm has just lifted part of the veil surrounding brain activity during sleep. Though we know that some neurons are reactivated then to consolidate our memories, we did not know how these cells could “remember” which order to turn on in. The researchers have discovered that reactivating neurons during sleep relies on activation that occurs during...
Researchers from CIRI - International Center for Research in Infectious Diseases in Lyon (Inserm, CNRS, ENS Lyon and Claude Bernard Lyon 1 University), supported by the ANRS, are demonstrating the link between activation of a bile acid receptor found in liver cells and the reduction in hepatitis B virus replication in mice infected with the virus.
