Several observational and clinical research projects on the monitoring of symptomatic pregnant women, monitoring of children with malformation of the nervous systems or born of infected mothers, construction of biobanks of biological specimens and samples, assessment of the penetration of the virus in populations, and mathematical modelling of its dynamics, have already begun. Teams working in the neuroscience area have also been assembled to begin projects on this theme in a coordinated manner, given the neurotropic nature of the Zika virus.
More specifically, projects strongly involving the French Departments in the Americas are concerned with the following:
In terms of diagnostics, the aim is to rapidly develop a reliable method at individual and population scale, particularly aimed at pregnant women and newborns, taking into account the variety of pathogens, particularly arboviruses, that co-circulate in countries where the Zika virus epidemic is rife.
Based on these initial elements, Inserm and its partners in the Aviesan alliance have responded to a European call for proposals. For the Aviesan partners, this means:
Scientists at the Institut Pasteur, CNRS and Inserm, together with a team from Switzerland*, have shown that the bacterial pathogen Legionella pneumophila (the causative agent of Legionnaires’ disease or legionellosis) has developed a specific strategy to target the host cell mitochondria, the ...