Christophe Bernard Directeur de recherche Inserm Unité Inserm 1106 Institut des neurosciences des systèmes email@example.com
Migration of neurons©Inserm / Christine Métin - Christophe BernardThe research team managed to identify the mechanism responsible for the deleterious effects of caffeine on the developing brain. During development, some cells are generated in specific cerebral regions, and later migrate to the regions where they will function. This is the case for neurons releasing GABA – a principal chemical mediator in the brain - which later migrate to, among other locations, the hippocampus, a brain region that plays a key role in memory formation. Caffeine directly influences the migration of these neurons, which contain a particular receptor called A2A. When caffeine binds to these A2A receptors, the migration speed of these neurons is decreased. The cells therefore reach their intended destination later than planned. This delayed migration affects the construction of the brain with effects seen at birth (cellular excitability and susceptibility to seizures) and during adulthood (loss of neurons and memory deficits on certain tests).
©Inserm / Christine Métin - Christophe BernardGiven their observations in mice, the authors suggest developing longitudinal studies---both short-term and, above all, long-term---to assess the consequences for newborns. Newborns may be exposed to caffeine, either during pregnancy and/or during breastfeeding, or if the child is treated for sleep apnea using a caffeine citrate based treatment.
After 40 years of research, researchers at the CEA, the CNRS, the University of Grenoble-Alps, the University of Montpellier and the Inserm have finally identified the enzyme responsible for the tubulin cycle. Surprisingly, it is not one enzyme but two which control ...
Will the radiology of the future come from machine learning? That is the view of Inserm and Inria researchers working in collaboration at the Université Grenoble Alpes who have developed a program able to localize and diagnose various types of brain tumors ...
Adenosine Receptor Antagonists Including Caffeine Alter Fetal Brain Development in Mice. Carla G. Silva,1,2,3* Christine Métin,4,5 Walid Fazeli,6 Nuno J. Machado,3 Sanja Darmopil,1,2,7 Pierre-Serge Launay,4,5 Antoine Ghestem,1,2 Marie-Pascale Nesa,1,2 Emilie Bassot,1,2 Eszter Szabó,3 Younis Baqi,8 Christa E. Müller,8 Angelo R. Tomé,3,9 Anton Ivanov,1,2 Dirk Isbrandt,6 Yuri Zilberter,1,2 Rodrigo A. Cunha,3,10 Monique Esclapez,1,2† Christophe Bernard1,2*†
1 AixMarseille Université, INS, 13005Marseille, France. 2 Inserm, UMR_S 1106, 13005Marseille, France. 3 Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal. 4 INSERM UMR-S 839, Institut du Fer à Moulin, 75005 Paris, France. 5 Université Pierre et Marie Curie, 75005 Paris, France. 6 Experimental Neuropediatrics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg,Germany. 7 Department of Anatomy, Croatian Institute for Brain Research, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia. 8 PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I, Pharmaceutical Sciences Bonn, University of Bonn, 53121 Bonn, Germany. 9 Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra,3030-790 Coimbra, Portugal. 10 Faculty of Medicine, University of Coimbra, 3004-504 Coimbra, Portugal.Science Translational Medicine, 07 août 2013 DOI : 10.1126/scitranslmed.3006258