BIOMEDE 1.0, sponsored and coordinated by Gustave Roussy, is the largest clinical trial ever conducted in diffuse intrinsic pontine glioma, an aggressive paediatric cancer in which survival rarely exceeds one year. The findings, published in the journal Nature Medicine, chart a new biological map of the disease, identify patient response biomarkers, and document the prolonged survival of four children — opening concrete avenues for the therapies of tomorrow. This...
Using fewer cosmetics and skincare products can quickly reduce exposure to several chemicals, including known or suspected endocrine disruptors, according to a study published on April 7 in Environment International by researchers from Inserm, the University of Grenoble Alpes, and the CNRS, at the Institute for the Advancement of Biosciences, and supported by the European Commission.
Patients with Alzheimer's disease have common biological alterations, including abnormal accumulation of the Tau protein in the brain. The mechanisms behind this abnormality may be on the verge of being elucidated. In a new study, a research team from Inserm, the University of Lille, and Lille University Hospital has revealed for the first time the role of tanycytes in the equation.
Sleep apnea affects nearly one billion people worldwide and causes repeated episodes of oxygen deprivation during the night, known as intermittent hypoxia. A study conducted by scientists from the University of Grenoble Alpes, Inserm, and Grenoble Alpes University Hospital, published today in the journal Science Advances, shows that these episodes reorganize the liver's biological clock, altering the daily rhythms of its metabolic activity.
In Paris, districts with more vegetation have a lower risk of death during periods of high heat, while highly mineralized areas with few green spaces and a high potential for urban heat islands are the most exposed.The scientists emphasize the importance of developing vegetation in cities and better distributing green spaces among neighborhoods to protect the health of Parisians in the face of global warming.
Researchers from Inserm and Paris Cité University, involved in the CORIMUNO-19 study promoted by AP-HP and funded by the Fondation pour la Recherche Médicale and ANRS Maladies infectieuses émergentes (ANRS MIE), have identified biological indicators that can predict 3-month mortality in patients hospitalised for COVID-19 pneumonia. Based on two renal and one immune markers obtained from a simple blood test, combined with patients' age, they have developed a new,...
A study by Inserm, in collaboration with the CNRS, the University of Grenoble Alpes (UGA), the Grenoble Alpes University Hospital (CHU), and the Barcelona Institute for Global Health (ISGlobal), suggests there may be an association between exposure in the third trimester of pregnancy to two synthetic phenols, methylparaben and bisphenol S, commonly found in everyday products (food, cosmetics, plastics, etc.), and questionnaire scores that could suggest behavioral disorders in...
A study conducted by Institut Curie and Inserm reveals that the presence of a compound present in cruciferous vegetables, indole-3-carbinol, is essential to make certain cancer treatments effective.
Two researchers from Inserm and one researcher from INRAE contributed to a series of three articles published on 19 November in The Lancet on the health consequences of consuming ultra-processed foods. The 43 international scientists who signed this series of articles propose the implementation of public health measures to limit the use of ultra-processed foods and improve nutrition worldwide.
While the role of certain air pollutants is now recognized in some cancers in adults, it has not yet been established in the case of acute leukemia in children. A team of researchers from Inserm, in collaboration with Sorbonne Paris Nord University, Paris Cité University, INRAE and Swiss researchers, used data from the GEOCAP-Birth study based on the national registry of childhood cancer to assess the risk of acute...
For the first time, a team of Inserm researchers from the Physics for Medicine Institute Paris (Inserm/ESPCI Paris-PSL/CNRS) has succeeded in mapping the blood flow of an entire organ in animals (heart, kidney and liver) with great precision, in four dimensions: 3D + time. This new imaging technique, when applied to humans, could both improve our understanding of the circulatory system (veins, arteries, vessels and lymphatic system) and facilitate...
