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Découverte d’une nouvelle cible d’intérêt thérapeutique dans l’hypertension artérielle

29 Jan 2010 | By INSERM (Newsroom) | Circulation, metabolism, nutrition

cp_loirand_290110 Angiotensine

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Gervaise Loirand
Unité Inserm 915 "Institut du thorax", Nantes
33 (0)2 28 08 01 16
rf.setnan-vinu@dnariol.esiavreg

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rf.mresni@esserp

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"The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure"


Christophe Guilluy1,2,8, Jérémy Brégeon1,2,8, Gilles Toumaniantz1,2, Malvyne Rolli-Derkinderen1,2, Kevin Retailleau3, Laurent Loufrani3, Daniel Henrion3, Elizabeth Scalbert4, Antoine Bril4, Raul M Torres5, Stephan Offermanns6, Pierre Pacaud1,2 & Gervaise Loirand1,2,7

(1)Inserm, U915, Nantes, France.
(2)University of Nantes, l’institut du thorax, Nantes, France.
(3)Inserm, U771 and CNRS UMR6214, Faculté de Médecine Angers, France.
(4)Institut de Recherches Servier, Suresnes, France.
(5)Integrated Department of Immunology, University of Colorado, Denver, Colorado, USA.
(6)Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.
(7)CHU Nantes, l’institut du thorax, Nantes, France.
(8)These authors contributed equally to this work.

Nature Medicine, 4 février 2010

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