Axl mediates ZIKA virus entry in human glial cells and modulates innate immune responses
Laurent Meertens 1, 2, 3 *, Athena Labeau 1, 2, 3, Ophelie Dejarnac 1, 2, 3, Sara Cipriani 4,,Laura Sinigaglia 5, Lucie Bonnet-Madin 1, 2 3, Tifenn Le Charpentier 4, Mohamed Lamine Hafirassou 1, 2, 3, Alessia Zamborlini 1, 2, 3, 6, Mai Cao-Lormeau 7, Muriel Coulpier 8, Dorothée Missé 9, Nolwenn Jouvenet 5, Ray Tabibiazar 10, Pierre Gressens 4, Olivier Schwartz 11 and Ali Amara 1, 2, 3 *
1 INSERM U944,-CNRS 7212 Laboratoire de Pathologie et Virologie Moléculaire, Hôpital Saint-
Louis 1 avenue Claude Vellefaux 75010, PARIS, France
2 Institut Universitaire d'Hématologie, Hôpital Saint-Louis, 1 avenue Claude Vellefaux. 75010
PARIS, France
3 University Paris Diderot, Sorbonne Paris Cité, Hôpital St. Louis 1, Avenue Claude Vellefaux
75475 Paris cedex 10 France
4 PROTECT, INSERM, Université Paris Diderot, Sorbonne Paris Cité, F-75019 Paris, France
5 UMR CNRS 3569, Viral Genomics and Vaccination Unit, Pasteur Institute, 75724 Paris, France
6 Laboratoire PVM, Conservatoire des Arts et Metiers, 292 Rue Saint-Martin, 75003 Paris,
France
7 Institut Louis Malardé, Papeete, Tahiti, French Polynesia.
8 ANSES, Université Paris-Est, Ecole Nationale Vétérinaire d’Alfort, UMR Virologie, Maisons-
Alfort, France
9 Laboratoire MIVEGEC, UMR 224 IRD/CNRS Montpellier, France
10 Ruga Corporation, Two Houston Center, 909 Fannin St, #2000, Houston, TX 77010-1018
11 Unité Virus et Immunité, Institut Pasteur, 28 rue du Dr Roux, 75724 PARIS, France.
A number of funding agencies contributed to this project: this work was supported by the European Union Horizon 2020 Research and Innovation Programme under ZIKAlliance Grant Agreement 734548, in association with NIH, Labex Integrative Biology of Emerging Infectious Diseases, the French National Research Agency ‘‘Investissements d’Avenir’’ and grant TIMTAMDEN.
Cell Reports, January 10th
http://dx.doi.org/10.1016/j.celrep.2016.12.045