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Immunoscore: a test to improve the care and treatment of colon cancer

Press release | 01 Jun 2018 - 15h00 | By INSERM PRESS OFFICE
Circulation, metabolism, nutrition

Crédits: Inserm/Sénégas-Balas, Françoise

With Immunoscore, a test devised by a team of researchers from Inserm and Université Paris Descartes and doctors from the Paris AP-HP hospitals, disease progression in patients with colon cancer can now be defined more accurately. According to an international study conducted in more than 2,500 patients, Immunoscore has proved effective in predicting which patients are at high risk of tumor recurrence and, as such, would benefit from intensified treatment following surgery. These results have been published in The Lancet.

The seriousness of cancer, and particularly that of the colon, is essentially estimated according to the extent to which it has spread within the affected organ and the presence of metastasis. This estimation of the aggressiveness of the cancer and its risk of recurrence following treatment must however be improved.

For decades, it has been thought that the immune reaction developed by the patient against his or her cancer has a beneficial influence. Researchers from Inserm and doctors from the Paris AP-HP hospitals have demonstrated in recent years that infiltration of the cancerous tumor by immune cells is a good indication of the way in which colorectal cancer might develop, thereby representing a potential prognostic tool. The immune cell populations which provide the most information on disease progression were identified and the method of evaluating these populations optimized.

This method has led to the creation of an immunological test, applicable in clinical practice, called “Immunoscore”. It works by quantifying the density of two types of immune cells in the tumor and its invasive margin: total T-cells (CD3+) and killer T-cells (cytotoxic CD8+).

The objective of this international study published in The Lancet was to evaluate the prognostic value of Immunoscore in patients with colon cancer on a very large scale. For this, an international consortium of 14 immunology and pathology centers in 13 countries was formed.  A total of 2,681 patients from these centers were included in this analysis. The prognostic performance of Immunoscore, in which patients are classified into 3 groups (high, intermediate and low), was evaluated on the basis of recurrence risk (evaluated during the 5 years following the surgery) and survival. The statistical analyses were all performed by a group of external biostatisticians from the Mayo Clinic in the USA.

The results show that patients with a high Immunoscore present the lowest recurrence risk and prolonged survival. 

In the test group comprising 700 patients, only 8% of those with a high Immunoscore presented a recurrence after 5 years. However, the recurrence rate increased significantly in patients with intermediate and low Immunoscores, reaching 19% and 32%, respectively.  These findings were confirmed in the two other patient groups analyzed, representing 1,981 patients. Furthermore, Immunoscore had a stronger bearing on patient survival than the tumor criteria which are currently used to guide therapy. 

These findings show that Immunoscore provides an accurate and reliable estimation of recurrence risk in patients with colon cancer. The researchers consider that these results support the use of Immunoscore as a new component in the classification of cancer, in which recurrence risk is used to improve individual patient treatment strategies, particularly the modulation of chemotherapy.

In view of the highly positive results of this test in colon cancer, researchers are currently evaluating Immunoscore in other types of cancer and are studying its ability to predict patient response to the immunotherapies which are currently revolutionizing the treatment of cancer.

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Press release – Inserm press room Immunoscore: a test to improve the care and treatment of colon cancer Link : https://presse.inserm.fr/en/immunoscore-a-test-to-improve-the-care-and-treatment-of-colon-cancer/31545/
Medias
Researcher Contact

Jérôme Galon

 Inserm Research Director

Inserm Unit 1138

Laboratory of Integrative Cancer Immunology

Cordeliers Research Centre, Paris, France.

Email: jerome.galon@crc.jussieu.fr

Tel.: +33 (0)1 44 27 90 85 

AP-HP physician contact

Prof. Franck Pagès

Director of the Immunomonitoring Platform, Biological Immunology Department

Hôpital Européen Georges Pompidou, AP-HP

Paris, France

Email: franck.pages@aphp.fr

Tel.: +33 (0)1 56 09 39 46

Press Contact

presse@inserm.fr

Sources

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

 

Franck Pagès, Bernhard Mlecnik, Florence Marliot, Gabriela Bindea, Fang-Shu Ou, Carlo Bifulco, Alessandro Lugli, Inti Zlobec, Tilman T Rau,Martin D Berger, Iris D Nagtegaal, Elisa Vink-Börger, Arndt Hartmann, Carol Geppert, Julie Kolwelter, Susanne Merkel, Robert Grützmann,Marc Van den Eynde, Anne Jouret-Mourin, Alex Kartheuser, Daniel Léonard, Christophe Remue, Julia Y Wang, P Bavi, Michael H A Roehrl,Pamela S Ohashi, Linh T Nguyen, SeongJun Han, Heather L MacGregor, Sara Hafezi-Bakhtiari, Bradly G Wouters, Giuseppe V Masucci,Emilia K Andersson, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova,

Kristyna Nemejcova, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Ciliberto, Michele Maio, Luigi Laghi, Fabio Grizzi, Tessa Fredriksen,Bénédicte Buttard, Mihaela Angelova, Angela Vasaturo, Pauline Maby, Sarah E Church, Helen K Angell, Lucie Lafontaine, Daniela Bruni, Carine El Sissy,Nacilla Haicheur, Amos Kirilovsky, Anne Berger, Christine Lagorce, Jeffrey P Meyers, Christopher Paustian, Carmen Ballesteros-Merino, Jeroen Dijkstra,Carlijn van de Water, Shannon van Lent- van Vliet, Nikki Knijn, Ana-Maria Mușină, Dragos-Viorel Scripcariu, Boryana Popivanova, Mingli Xu,Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Toshihiko Torigoe, Noriyuki Sato, Tomohisa Furuhata,Ichiro Takemasa, Kyogo Itoh, Prabhu S Patel, Hemangini H Vora, Birva Shah, Jayendrakumar B Patel, Kruti N Rajvik, Shashank J Pandya, Shilin N Shukla,Yili Wang, Guanjun Zhang, Yutaka Kawakami, Francesco M Marincola , Paolo A Ascierto, Daniel J Sargent*, Bernard A Fox, Jérôme Galon

 

INSERM, Laboratory of Integrative Cancer Immunology, Paris, France (F Pagès, B Mlecnik, F Marliot, G Bindea, T Fredriksen, B Buttard, M Angelova, A Vasaturo, P Maby, S E Church, H K Angell, L Lafontaine, D Bruni, C El Sissy, A Kirilovsky PhD, Prof A Berger PhD, C Lagorce PhD, J Galon PhD);

Université Paris Descartes, Sorbonne Paris Cité, Paris, France (Prof F Pagès, B Mlecnik, F Marliot, G Bindea, T Fredriksen, B Buttard, M Angelova, A Vasaturo, P Maby, S E Church, H K Angell, L Lafontaine, D Bruni, C El Sissy, A Kirilovsky, A Berger, C Lagorce, J Galon);

Cordeliers Research Centre, Université Pierre et Marie Curie, Sorbonne Universités, Paris, France (F Pagès, B Mlecnik, F Marliot, G Bindea, T Fredriksen, B Buttard, M Angelova, A Vasaturo, P Maby, S E Church, H K Angell, L Lafontaine, D Bruni, C El Sissy, A Kirilovsky, A Berger, C Lagorce, J Galon);

Immunomonitoring Platform, Laboratory of Immunology, AP-HP, Assistance Publique-Hopitaux de Paris, Georges Pompidou European Hospital, Paris, France (F Pagès, F Marliot, C El Sissy, N Haicheur, A Kirilovsky);

Inovarion, Paris, France (B Mlecnik)

 

The Lancet, May 2018 https://doi.org/10.1016/S0140-6736(18)30789-X

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