Charcot-Marie Tooth disease is the most common hereditary neurological disease in the world. It affects the peripheral nerves and causes progressive paralysis of the legs and hands. No treatment is currently available to fight this disease, which is due to the overexpression of a specific protein.
Lorsque nous rêvons, nous sommes à première vue coupés du monde, incapables de recevoir des informations de l’environnement et d’y répondre. Pour la première fois, une collaboration entre des chercheurs de l’Inserm, de l’AP-HP, de Sorbonne Université et du CNRS avec plusieurs groupes américains, allemands et néerlandais, montre qu’une communication à double-sens, de l’expérimentateur vers le rêveur et vice-versa est possible au cours du rêve.
Elderly women are currently at a higher risk than men of developing dementia, particularly Alzheimer's disease. A phenomenon that could partially be explained by inequalities in access to education between the sexes during the first half of the 20th century. Researchers from Inserm and Université de Paris, in collaboration with University College London, have shown that certain cognitive capacities have improved in women over recent generations, and that this...
Are our emotions innate or are they the product of our culture and environment? This question has long been the subject of debate in the field of neuroscience. Researchers provide robust clinical data in favor of the second hypothesis. Their work suggests that our ability to know and recognize emotions is built up gradually and depends on our knowledge of language.
Dysfunctions of ion channels - or channelopathies - in the brain are today associated with more than 30 neurological diseases such as epilepsy or cerebellar ataxias. A study conducted at the Brain Institute (Sorbonne University / Inserm / AP-HP / CNRS) identified a new cerebral channelopathy originating from dominant mutations in the KCNN2 gene, encoding the SK2 ion channel.
A research team from Inserm, Lille teaching hospital and Université de Lille working at the Lille Neuroscience and Cognition Laboratory has discovered in mice a mechanism associated with the prepubertal growth spurt and the triggering of early puberty. This mechanism is regulated by the GnRH neurons, which orchestrate fertility, through the expression of their protein Nrp1.
Les données d'une nouvelle étude confirment que le traitement par hormone de croissance suite à une radiothérapie chez les enfants qui présentent un déficit de cette hormone n’augmente pas le risque de survenue d’un second cancer.
Huntington's disease is a genetic neurological condition that usually manifests in adulthood. Teams of researchers and clinicians from Inserm, Université Grenoble Alpes, Sorbonne Université, CNRS and AP-HP at the Grenoble Institute of Neuroscience and the Brain Institute, have discovered abnormalities in the brains of human embryos that carry the mutation responsible for Huntington's disease.
Cannabis use can lead to behavioral changes, including reduced social interactions in some individuals. To better understand the phenomenon, Inserm researcher Giovanni Marsicano and his team from NeuroCenter Magendie (Inserm/Université de Bordeaux), in collaboration with Juan Bolaños' team from the University of Salamanca, have identified for the first time in mice the cerebral mechanisms underlying the relationship between cannabis and reduced sociability.
A study, aimed at identifying the risk factors for the severity of COVID-19 in patients with multiple sclerosis in France, was carried out by teams from the neurology department of the Pitié-Salpêtrière hospital AP -HP, from the Brain Institute (Inserm / CNRS / Sorbonne University) at the Pitié-Salpêtrière hospital AP-HP, from Sorbonne University and the neurology service of the Strasbourg CHU.