A large number of researchers are currently mobilized to increase knowledge of SARS-CoV-2 in order to improve the treatment of infected patients and try to predict the future health impacts of infection with the virus. Researchers have been the first to identify a direct effect of SARS-CoV-2 on the brain’s blood vessels.
How can lost neurons be regenerated? Using an animal model of epilepsy, the researchers have succeeded in transforming non-neuronal cells in the brain into new inhibitory neurons that reduce chronic epileptic activity by half. This research will in time make it possible to envisage a therapeutic application of this strategy.
Teams from Inserm, CNRS, AP-HP and Sorbonne University, grouped together within the Brain Institute at Pitié-Salpêtrière AP-HP hospital and coordinated by Dr Matthieu Peyre and Prof. Michel Kalamarides, studied the presence of mutations in the PIK3CA genes in cavernomas.
To increase their understanding of the disease, a team of researchers has for several years studied the role of leptin, a hormone involved in appetite control that sends satiety signals to the brain.
Les directions générales de l’ANSES, du CEA, du CNRS, d’INRAE et de l’Inserm, ont décidé conjointement et en accord avec le ministère de l’enseignement supérieur, de la recherche et de l’innovation de suspendre à titre conservatoire l’ensemble de leurs travaux de recherche et d’expérimentation relatifs aux maladies à prions, pour une durée de trois mois.
Des chercheurs révèlent le rôle crucial des astrocytes dans la fermeture de la période de plasticité cérébrale qui suit la naissance. Ces travaux permettent d’envisager de nouvelles stratégies pour ré-introduire la plasticité cérébrale chez l’adulte, et ainsi favoriser la rééducation après des lésions cérébrales ou des troubles neuro-développementaux.
Troubles de la marche et de l’équilibre, douleurs, atrophie musculaire… c’est le quotidien des 30 000 à 50 000 patients souffrant des maladies de Charcot-Marie-Tooth (CMT) en France. Des chercheurs de l'Inserm, de l’Université de Montpellier à l’Institut des Neurosciences de Montpellier (INM) et à l’Institut de médecine régénérative et de biothérapie (IRMB), en collaboration avec l’ISTEM à Evry, viennent d’obtenir des résultats prometteurs en ayant recours à un...
For the past 30 years, it was thought that the brain – responsible for motor control – worked to continuously compensate for the effects of gravity. In an initial study in 2016, the researchers had suggested that our brains use gravity to minimize the effort our muscles have to make. Those results were recently confirmed by new experiments conducted in collaboration with New York University on non-human primate models...
In anorexia nervosa patients, the weight loss through lack of food is accompanied by fatigue and reduced physical capacity. Yet despite this they often continue to perform intense physical activity which contributes to that weight loss.
Huntington's disease is a hereditary disorder that causes degeneration of the neurons involved in cognitive, motor and psychiatric functions. While existing treatments address the symptoms and relieve certain aspects of the disease, they cannot alter its course.