Seasonal influenza is a major public health issue because it continues to remain associated with considerable mortality, particularly among people who are elderly, immunocompromised, or both. With vaccination and current treatments still being of limited efficacy, research teams are trying to develop new therapeutic approaches. Scientists have shown that in a context of influenza infection, a metabolite called succinate, which is naturally present in the body, has an antiviral...
In a new study, researchers investigated a receptor found on male germ cells that produce gametes, their aim being to find out more about its role in chemotherapy-related infertility. Their findings pave the way for a better understanding of male infertility and the development of treatments to reduce the risk of sterility from chemotherapy.
Dans une nouvelle étude, des scientifiques ont identifié, à partir des données de près de 26 000 volontaires de la cohorte Constances, quels symptômes persistants sont le plus fréquemment rapportés par les personnes ayant été infectées par le SARS-CoV-2 comparé au reste de la population. Il s’agit principalement de la perte de goût ou d’odorat, de gêne respiratoire ou de fatigue.
A very small percentage of people with HIV-1, known as "post-treatment controllers" (PTCs), are able to control their infection after interrupting all antiretroviral therapy. Understanding the fundamental mechanisms that govern their immune response is essential in order to develop HIV-1 vaccines, novel therapeutic strategies to achieve remission, or both. A recent study investigated the humoral immune response – also known as antibody-mediated immunity – in some PTCs in whom...
Researchers have studied the impact of individual sociodemographic, behavioral and health factors on the practice of daily physical activity in later life, using data from 3,896 participants of the Whitehall II cohort. This research highlights the complexity of individual barriers to an active lifestyle among older adults and suggests that this complexity should be better taken into account when redefining public health policies.
In order to evaluate the risk of cancer linked to them, researchers analyzed data relating to the health of 102,865 French adults participating in the NutriNet-Santé cohort study and their consumption of artificial sweeteners. The results of these statistical analyses suggest a link between the consumption of artificial sweeteners and an increased risk of cancer.
Studies have shown that the risk of ischemic stroke is increased by the use of antipsychotics: medications with antidopaminergic properties that are commonly prescribed in psychiatry. Researchers evaluated the ischemic stroke risk associated with exposure to other antidopaminergic medications—antiemetics, which are very commonly used in the symptomatic treatment of nausea and vomiting. The findings of this study, show a link between the use of these medications and the risk...
A new modeling study by researchers from Inserm and Sorbonne Université at the Pierre Louis Institute of Epidemiology and Public Health shows that a "reactive" vaccination strategy targeting homes, schools and workplaces where cases are detected could have beneficial effects, reducing the number of COVID-19 cases in certain epidemic situations.
In a new study, researchers from Inserm and Université de Bordeaux at the Bordeaux Population Health Research Center, in collaboration with the Research Institute for Sustainable Development (IRD) and the NGO ALIMA (The Alliance for International Medical Action), have developed and tested a new strategy to simplify and optimize the treatment of malnutrition in order to help a larger number of children.
Researchers report that the MICA gene is a new histocompatibility gene, in that it helps to better explain and predict the success or failure of a kidney transplant. Their findings have been published in Nature Medicine.
